A procedure for creating a frailty index based on deficit accumulation in aging mice

Randi J. Parks; Elias Fares; Jennifer K. MacDonald; Matthew C. Ernst; Christopher J. Sinal; Kenneth Rockwood; Susan E. Howlett

doi:10.1093/gerona/glr193

A procedure for creating a frailty index based on deficit accumulation in aging mice

Randi J. Parks, Elias Fares, Jennifer K. MacDonald, Matthew C. Ernst, Christopher J. Sinal, Kenneth Rockwood, Susan E. Howlett

Research output: Contribution to journal › Article › peer-review

Abstract

This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p

Original language	English
Pages (from-to)	217-227
Number of pages	10
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	67
Issue number	3
DOIs	https://doi.org/10.1093/gerona/glr193
Publication status	Published - Mar 2012

Keywords

Calcium transient
Contraction
Deficit index
Excitation-contraction coupling
Frailty index

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abstract = "This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p",

keywords = "Calcium transient, Contraction, Deficit index, Excitation-contraction coupling, Frailty index",

author = "Parks, {Randi J.} and Elias Fares and MacDonald, {Jennifer K.} and Ernst, {Matthew C.} and Sinal, {Christopher J.} and Kenneth Rockwood and Howlett, {Susan E.}",

note = ", Canadian Institutes of Health Research, Canada",

year = "2012",

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T1 - A procedure for creating a frailty index based on deficit accumulation in aging mice

AU - Parks, Randi J.

AU - Fares, Elias

AU - MacDonald, Jennifer K.

AU - Ernst, Matthew C.

AU - Sinal, Christopher J.

AU - Rockwood, Kenneth

AU - Howlett, Susan E.

N1 - , Canadian Institutes of Health Research, Canada

PY - 2012/3

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AB - This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p

KW - Calcium transient

KW - Contraction

KW - Deficit index

KW - Excitation-contraction coupling

KW - Frailty index

U2 - 10.1093/gerona/glr193

DO - 10.1093/gerona/glr193

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JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 3

ER -

A procedure for creating a frailty index based on deficit accumulation in aging mice

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Keywords

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