A radiation hybrid map of the rat genome containing 5,255 markers

Takeshi K. Watanabe, Marie Therese Bihoreau, Linda C. McCarthy, Susanna L. Kiguwa, Haretsugu Hishigaki, Atsushi Tsuji, Julie Browne, Yuki Yamasaki, Ayako Mizoguchi-Miyakita, Keiko Oga, Toshihide Ono, Shiro Okuno, Naohide Kanemoto, Ei Ichi Takahashi, Kazuhiro Tomita, Hiromi Hayashi, Masakazu Adachi, Caleb Webber, Marie Davis, Susanne KielCatherine Knights, Angela Smith, Ricky Critcher, Jonathan Miller, Thiru Thangarajah, Philip J R Day, James R. Hudson, Yasuo Irie, Toshihisa Takagi, Yusuke Nakamura, Peter N. Goodfellow, G. Mark Lathrop, Akira Tanigami, Michael R. James

    Research output: Contribution to journalArticlepeer-review


    A whole-genome radiation hybrid (RH) panel was used to construct a high- resolution map of the rat genome based on microsatellite and gene markers. These include 3,019 new microsatellite markers described here for the first time and 1,714 microsatellite markers with known genetic locations, allowing comparison and integration of maps from different sources. A robust RH framework map containing 1,030 positions ordered with odds of at least 1,000:1 has been defined as a tool for mapping these markers, and for future RH mapping in the rat. More than 500 genes which have been mapped in mouse and/or human were localized with respect to the rat RH framework, allowing the construction of detailed rat-mouse and rat-human comparative maps and illustrating the power of the RH approach for comparative mapping.
    Original languageEnglish
    Pages (from-to)27-36
    Number of pages9
    JournalNature Genetics
    Issue number1
    Publication statusPublished - May 1999


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