A radiation hybrid map of the rat genome containing 5,255 markers

Takeshi K. Watanabe; Marie Therese Bihoreau; Linda C. McCarthy; Susanna L. Kiguwa; Haretsugu Hishigaki; Atsushi Tsuji; Julie Browne; Yuki Yamasaki; Ayako Mizoguchi-Miyakita; Keiko Oga; Toshihide Ono; Shiro Okuno; Naohide Kanemoto; Ei Ichi Takahashi; Kazuhiro Tomita; Hiromi Hayashi; Masakazu Adachi; Caleb Webber; Marie Davis; Susanne Kiel; Catherine Knights; Angela Smith; Ricky Critcher; Jonathan Miller; Thiru Thangarajah; Philip J R Day; James R. Hudson; Yasuo Irie; Toshihisa Takagi; Yusuke Nakamura; Peter N. Goodfellow; G. Mark Lathrop; Akira Tanigami; Michael R. James

doi:10.1038/8737

A radiation hybrid map of the rat genome containing 5,255 markers

Takeshi K. Watanabe, Marie Therese Bihoreau, Linda C. McCarthy, Susanna L. Kiguwa, Haretsugu Hishigaki, Atsushi Tsuji, Julie Browne, Yuki Yamasaki, Ayako Mizoguchi-Miyakita, Keiko Oga, Toshihide Ono, Shiro Okuno, Naohide Kanemoto, Ei Ichi Takahashi, Kazuhiro Tomita, Hiromi Hayashi, Masakazu Adachi, Caleb Webber, Marie Davis, Susanne KielCatherine Knights, Angela Smith, Ricky Critcher, Jonathan Miller, Thiru Thangarajah, Philip J R Day, James R. Hudson, Yasuo Irie, Toshihisa Takagi, Yusuke Nakamura, Peter N. Goodfellow, G. Mark Lathrop, Akira Tanigami, Michael R. James

Research output: Contribution to journal › Article › peer-review

Abstract

A whole-genome radiation hybrid (RH) panel was used to construct a high- resolution map of the rat genome based on microsatellite and gene markers. These include 3,019 new microsatellite markers described here for the first time and 1,714 microsatellite markers with known genetic locations, allowing comparison and integration of maps from different sources. A robust RH framework map containing 1,030 positions ordered with odds of at least 1,000:1 has been defined as a tool for mapping these markers, and for future RH mapping in the rat. More than 500 genes which have been mapped in mouse and/or human were localized with respect to the rat RH framework, allowing the construction of detailed rat-mouse and rat-human comparative maps and illustrating the power of the RH approach for comparative mapping.

Original language	English
Pages (from-to)	27-36
Number of pages	9
Journal	Nature Genetics
Volume	22
Issue number	1
DOIs	https://doi.org/10.1038/8737
Publication status	Published - May 1999

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Watanabe, T. K., Bihoreau, M. T., McCarthy, L. C., Kiguwa, S. L., Hishigaki, H., Tsuji, A., Browne, J., Yamasaki, Y., Mizoguchi-Miyakita, A., Oga, K., Ono, T., Okuno, S., Kanemoto, N., Takahashi, E. I., Tomita, K., Hayashi, H., Adachi, M., Webber, C., Davis, M., ... James, M. R. (1999). A radiation hybrid map of the rat genome containing 5,255 markers. Nature Genetics, 22(1), 27-36. https://doi.org/10.1038/8737

@article{faef28722d1e4bb9babf4b7f5fd62438,

title = "A radiation hybrid map of the rat genome containing 5,255 markers",

abstract = "A whole-genome radiation hybrid (RH) panel was used to construct a high- resolution map of the rat genome based on microsatellite and gene markers. These include 3,019 new microsatellite markers described here for the first time and 1,714 microsatellite markers with known genetic locations, allowing comparison and integration of maps from different sources. A robust RH framework map containing 1,030 positions ordered with odds of at least 1,000:1 has been defined as a tool for mapping these markers, and for future RH mapping in the rat. More than 500 genes which have been mapped in mouse and/or human were localized with respect to the rat RH framework, allowing the construction of detailed rat-mouse and rat-human comparative maps and illustrating the power of the RH approach for comparative mapping.",

author = "Watanabe, {Takeshi K.} and Bihoreau, {Marie Therese} and McCarthy, {Linda C.} and Kiguwa, {Susanna L.} and Haretsugu Hishigaki and Atsushi Tsuji and Julie Browne and Yuki Yamasaki and Ayako Mizoguchi-Miyakita and Keiko Oga and Toshihide Ono and Shiro Okuno and Naohide Kanemoto and Takahashi, {Ei Ichi} and Kazuhiro Tomita and Hiromi Hayashi and Masakazu Adachi and Caleb Webber and Marie Davis and Susanne Kiel and Catherine Knights and Angela Smith and Ricky Critcher and Jonathan Miller and Thiru Thangarajah and Day, {Philip J R} and Hudson, {James R.} and Yasuo Irie and Toshihisa Takagi and Yusuke Nakamura and Goodfellow, {Peter N.} and Lathrop, {G. Mark} and Akira Tanigami and James, {Michael R.}",

note = "JournalMAY192TUNAT GENET",

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doi = "10.1038/8737",

language = "English",

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Watanabe, TK, Bihoreau, MT, McCarthy, LC, Kiguwa, SL, Hishigaki, H, Tsuji, A, Browne, J, Yamasaki, Y, Mizoguchi-Miyakita, A, Oga, K, Ono, T, Okuno, S, Kanemoto, N, Takahashi, EI, Tomita, K, Hayashi, H, Adachi, M, Webber, C, Davis, M, Kiel, S, Knights, C, Smith, A, Critcher, R, Miller, J, Thangarajah, T, Day, PJR, Hudson, JR, Irie, Y, Takagi, T, Nakamura, Y, Goodfellow, PN, Lathrop, GM, Tanigami, A & James, MR 1999, 'A radiation hybrid map of the rat genome containing 5,255 markers', Nature Genetics, vol. 22, no. 1, pp. 27-36. https://doi.org/10.1038/8737

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T1 - A radiation hybrid map of the rat genome containing 5,255 markers

AU - Watanabe, Takeshi K.

AU - Bihoreau, Marie Therese

AU - McCarthy, Linda C.

AU - Kiguwa, Susanna L.

AU - Hishigaki, Haretsugu

AU - Tsuji, Atsushi

AU - Browne, Julie

AU - Yamasaki, Yuki

AU - Mizoguchi-Miyakita, Ayako

AU - Oga, Keiko

AU - Ono, Toshihide

AU - Okuno, Shiro

AU - Kanemoto, Naohide

AU - Takahashi, Ei Ichi

AU - Tomita, Kazuhiro

AU - Hayashi, Hiromi

AU - Adachi, Masakazu

AU - Webber, Caleb

AU - Davis, Marie

AU - Kiel, Susanne

AU - Knights, Catherine

AU - Smith, Angela

AU - Critcher, Ricky

AU - Miller, Jonathan

AU - Thangarajah, Thiru

AU - Day, Philip J R

AU - Hudson, James R.

AU - Irie, Yasuo

AU - Takagi, Toshihisa

AU - Nakamura, Yusuke

AU - Goodfellow, Peter N.

AU - Lathrop, G. Mark

AU - Tanigami, Akira

AU - James, Michael R.

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N2 - A whole-genome radiation hybrid (RH) panel was used to construct a high- resolution map of the rat genome based on microsatellite and gene markers. These include 3,019 new microsatellite markers described here for the first time and 1,714 microsatellite markers with known genetic locations, allowing comparison and integration of maps from different sources. A robust RH framework map containing 1,030 positions ordered with odds of at least 1,000:1 has been defined as a tool for mapping these markers, and for future RH mapping in the rat. More than 500 genes which have been mapped in mouse and/or human were localized with respect to the rat RH framework, allowing the construction of detailed rat-mouse and rat-human comparative maps and illustrating the power of the RH approach for comparative mapping.

AB - A whole-genome radiation hybrid (RH) panel was used to construct a high- resolution map of the rat genome based on microsatellite and gene markers. These include 3,019 new microsatellite markers described here for the first time and 1,714 microsatellite markers with known genetic locations, allowing comparison and integration of maps from different sources. A robust RH framework map containing 1,030 positions ordered with odds of at least 1,000:1 has been defined as a tool for mapping these markers, and for future RH mapping in the rat. More than 500 genes which have been mapped in mouse and/or human were localized with respect to the rat RH framework, allowing the construction of detailed rat-mouse and rat-human comparative maps and illustrating the power of the RH approach for comparative mapping.

U2 - 10.1038/8737

DO - 10.1038/8737

M3 - Article

SN - 1061-4036

VL - 22

SP - 27

EP - 36

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

A radiation hybrid map of the rat genome containing 5,255 markers

Abstract

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