A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

Katie Z. Chapman; Verity Q. Dale; Ádám Dénes; Gavin Bennett; Nancy J. Rothwell; Stuart M. Allan; Barry W. McColl

doi:10.1038/jcbfm.2009.113

A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

Katie Z. Chapman, Verity Q. Dale, Ádám Dénes, Gavin Bennett, Nancy J. Rothwell, Stuart M. Allan, Barry W. McColl

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Abstract

Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis. © 2009 ISCBFM All rights reserved.

Original language	English
Pages (from-to)	1764-1768
Number of pages	4
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	29
Issue number	11
DOIs	https://doi.org/10.1038/jcbfm.2009.113
Publication status	Published - 2009

Keywords

Chemokine
CXCL-1
Interleukin-6
MCAo
Peripheral inflammation
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/jcbfm.2009.113

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title = "A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke",

abstract = "Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis. {\textcopyright} 2009 ISCBFM All rights reserved.",

keywords = "Chemokine, CXCL-1, Interleukin-6, MCAo, Peripheral inflammation, Stroke",

author = "Chapman, {Katie Z.} and Dale, {Verity Q.} and {\'A}d{\'a}m D{\'e}nes and Gavin Bennett and Rothwell, {Nancy J.} and Allan, {Stuart M.} and McColl, {Barry W.}",

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doi = "10.1038/jcbfm.2009.113",

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volume = "29",

pages = "1764--1768",

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T1 - A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

AU - Chapman, Katie Z.

AU - Dale, Verity Q.

AU - Dénes, Ádám

AU - Bennett, Gavin

AU - Rothwell, Nancy J.

AU - Allan, Stuart M.

AU - McColl, Barry W.

PY - 2009

Y1 - 2009

N2 - Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis. © 2009 ISCBFM All rights reserved.

AB - Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis. © 2009 ISCBFM All rights reserved.

KW - Chemokine

KW - CXCL-1

KW - Interleukin-6

KW - MCAo

KW - Peripheral inflammation

KW - Stroke

U2 - 10.1038/jcbfm.2009.113

DO - 10.1038/jcbfm.2009.113

M3 - Article

C2 - 19654587

SN - 1559-7016

VL - 29

SP - 1764

EP - 1768

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 11

ER -

A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

Abstract

Keywords

UN SDGs

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