A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

William Matthews; Craig T. Jordan; Marc Gavin; Nancy A. Jenkins; Neal G. Copeland; Ihor R. Lemischka

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

William Matthews, Craig T. Jordan, Marc Gavin, Nancy A. Jenkins, Neal G. Copeland, Ihor R. Lemischka

Research output: Contribution to journal › Article › peer-review

Abstract

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

Original language	English
Pages (from-to)	9026-9030
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	20
Publication status	Published - 15 Oct 1991

Keywords

Hematopoietic stem cell
Protein-tyrosine kinase

Cite this

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title = "A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit",

abstract = "We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.",

keywords = "Hematopoietic stem cell, Protein-tyrosine kinase",

author = "William Matthews and Jordan, {Craig T.} and Marc Gavin and Jenkins, {Nancy A.} and Copeland, {Neal G.} and Lemischka, {Ihor R.}",

note = "CA45339, NCI NIH HHS, United StatesDK42989, NIDDK NIH HHS, United StatesN01-CO-74101, NCI NIH HHS, United States",

year = "1991",

month = oct,

day = "15",

language = "English",

volume = "88",

pages = "9026--9030",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

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}

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. / Matthews, William; Jordan, Craig T.; Gavin, Marc et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 20, 15.10.1991, p. 9026-9030.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

AU - Matthews, William

AU - Jordan, Craig T.

AU - Gavin, Marc

AU - Jenkins, Nancy A.

AU - Copeland, Neal G.

AU - Lemischka, Ihor R.

N1 - CA45339, NCI NIH HHS, United StatesDK42989, NIDDK NIH HHS, United StatesN01-CO-74101, NCI NIH HHS, United States

PY - 1991/10/15

Y1 - 1991/10/15

N2 - We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

AB - We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.

KW - Hematopoietic stem cell

KW - Protein-tyrosine kinase

M3 - Article

C2 - 1717995

SN - 0027-8424

VL - 88

SP - 9026

EP - 9030

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 20

ER -

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

Abstract

Keywords

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