A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

William Matthews, Craig T. Jordan, Gordon W. Wiegand, Drew Pardoll, Ihor R. Lemischka

    Research output: Contribution to journalArticlepeer-review

    Abstract

    To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny.
    Original languageEnglish
    Pages (from-to)1143-1152
    Number of pages9
    JournalCell
    Volume65
    Issue number7
    Publication statusPublished - 1991

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