A review of paradoxical HDL-C responses to fenofibrate, illustrated by a case report.

Jonathan D Schofield; Yifen Liu; Michael W France; Lance Sandle; Handrean Soran

doi:10.1016/j.jacl.2014.05.003

A review of paradoxical HDL-C responses to fenofibrate, illustrated by a case report.

Jonathan D Schofield, Yifen Liu, Michael W France, Lance Sandle, Handrean Soran

Research output: Contribution to journal › Article › peer-review

Abstract

High-density lipoprotein cholesterol (HDL-C) concentration is an independent risk factor for cardiovascular disease. Fibrates are widely used in the management of atherogenic dyslipidemia, principally for their triglyceride-lowering and HDL-C-raising effects. Fibrates may cause paradoxical reductions in HDL-C. These reductions are usually modest, but significant reductions have been observed. The molecular mechanism for these paradoxical reductions remains unexplained despite advances in our understanding of lipid metabolism. This review considers possible mechanisms for this effect, illustrated by a patient with an observed reduction in HDL-C of 88% after introduction of fenofibrate.

Original language	English
Pages (from-to)	455-459
Number of pages	4
Journal	Journal of Clinical Lipidology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.jacl.2014.05.003
Publication status	Published - Jul 2014

Keywords

Fenofibrate
HDL
High-density lipoprotein
High-density lipoprotein cholesterol
Paradoxical reduction in high-density lipoprotein cholesterol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacl.2014.05.003

http://www.elsevier.com/wps/find/journaldescription.cws_home/710566/description#description

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title = "A review of paradoxical HDL-C responses to fenofibrate, illustrated by a case report.",

abstract = "High-density lipoprotein cholesterol (HDL-C) concentration is an independent risk factor for cardiovascular disease. Fibrates are widely used in the management of atherogenic dyslipidemia, principally for their triglyceride-lowering and HDL-C-raising effects. Fibrates may cause paradoxical reductions in HDL-C. These reductions are usually modest, but significant reductions have been observed. The molecular mechanism for these paradoxical reductions remains unexplained despite advances in our understanding of lipid metabolism. This review considers possible mechanisms for this effect, illustrated by a patient with an observed reduction in HDL-C of 88% after introduction of fenofibrate.",

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author = "Schofield, {Jonathan D} and Yifen Liu and France, {Michael W} and Lance Sandle and Handrean Soran",

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AU - Schofield, Jonathan D

AU - Liu, Yifen

AU - France, Michael W

AU - Sandle, Lance

AU - Soran, Handrean

N1 - , Wellcome Trust, United Kingdom

PY - 2014/7

Y1 - 2014/7

N2 - High-density lipoprotein cholesterol (HDL-C) concentration is an independent risk factor for cardiovascular disease. Fibrates are widely used in the management of atherogenic dyslipidemia, principally for their triglyceride-lowering and HDL-C-raising effects. Fibrates may cause paradoxical reductions in HDL-C. These reductions are usually modest, but significant reductions have been observed. The molecular mechanism for these paradoxical reductions remains unexplained despite advances in our understanding of lipid metabolism. This review considers possible mechanisms for this effect, illustrated by a patient with an observed reduction in HDL-C of 88% after introduction of fenofibrate.

AB - High-density lipoprotein cholesterol (HDL-C) concentration is an independent risk factor for cardiovascular disease. Fibrates are widely used in the management of atherogenic dyslipidemia, principally for their triglyceride-lowering and HDL-C-raising effects. Fibrates may cause paradoxical reductions in HDL-C. These reductions are usually modest, but significant reductions have been observed. The molecular mechanism for these paradoxical reductions remains unexplained despite advances in our understanding of lipid metabolism. This review considers possible mechanisms for this effect, illustrated by a patient with an observed reduction in HDL-C of 88% after introduction of fenofibrate.

KW - Fenofibrate

KW - HDL

KW - High-density lipoprotein

KW - High-density lipoprotein cholesterol

KW - Paradoxical reduction in high-density lipoprotein cholesterol

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DO - 10.1016/j.jacl.2014.05.003

M3 - Article

C2 - 25110229

SN - 1933-2874

VL - 8

SP - 455

EP - 459

JO - Journal of Clinical Lipidology

JF - Journal of Clinical Lipidology

IS - 4

ER -

A review of paradoxical HDL-C responses to fenofibrate, illustrated by a case report.

Abstract

Keywords

UN SDGs

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