Abstract
The unique characteristics of perfluoropolyether (PFPE) to fabricate monodisperse, shape and size specific particles ranging from a nanometer to micrometer size regime is utilized by Particle Replication in Non-wetting Templates (PRINT). Precisely engineered particles are produced by lithographic techniques derived from the microelectronics industry that has the nano-scale precision and spatial resolution thereby working as a platform for drug delivery. Here we describe the strategy for formulation, a ‘Top-down’ approach and delivery of small molecules not restricted to biological therapeutics using the PRINT technology; where particle size, shape and chemistry has been involved in a great extent in enhancing the systemic particle distribution properties and independent control of surfaces functionality. Further, the particular interest due to pharmaceutical needs for increased control over dry powder drug delivery and high therapeutic indices towards respiratory drug delivery has an important application of PRINT technology. Construction of liposomes, dendrimers and colloidal precipitates at nano-scale has adavantages when we speak of engineered nature of particle production. The edge of PRINT technology lies in its cargo carrying capacity including small organic therapeutics, biomolecules, macromolecules; allowing a nano scale range facile incorporation of water soluble drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 62-66 |
| Number of pages | 5 |
| Journal | International Journal of Advanced Information Science and Technology |
| Volume | 3 |
| Issue number | 1 |
| Publication status | Published - 2014 |