A role for β-melanocyte-stimulating hormone in human body-weight regulation

Heike Biebermann; Tamara R. Castañeda; Frank van Landeghem; Andreas von Deimling; Frederike Escher; Georg Brabant; Johannes Hebebrand; Anke Hinney; Matthias H. Tschöp; Annette Grüters; Heiko Krude

doi:10.1016/j.cmet.2006.01.007

A role for β-melanocyte-stimulating hormone in human body-weight regulation

Heike Biebermann, Tamara R. Castañeda, Frank van Landeghem, Andreas von Deimling, Frederike Escher, Georg Brabant, Johannes Hebebrand, Anke Hinney, Matthias H. Tschöp, Annette Grüters, Heiko Krude

Research output: Contribution to journal › Article › peer-review

Abstract

Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on α-melanocyte-stimulating hormone (α-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide β-MSH (Y5C-β-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide β-MSH plays a critical role in the hypothalamic control of body weight in humans. © 2006 Elsevier Inc.

Original language	English
Pages (from-to)	141-146
Number of pages	5
Journal	Cell Metabolism
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2006.01.007
Publication status	Published - Feb 2006

Keywords

Amino Acid Sequence
Base Sequence
genetics: Body Weight
genetics: Energy Metabolism
Genetic Screening
genetics: Homeostasis
Humans
metabolism: Hypothalamus
Immunohistochemistry
Molecular Sequence Data
genetics: Mutation, Missense
genetics: Obesity
Sequence Alignment
Sequence Analysis, DNA
genetics: beta-MSH

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2006.01.007

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title = "A role for β-melanocyte-stimulating hormone in human body-weight regulation",

abstract = "Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on α-melanocyte-stimulating hormone (α-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide β-MSH (Y5C-β-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide β-MSH plays a critical role in the hypothalamic control of body weight in humans. {\textcopyright} 2006 Elsevier Inc.",

keywords = "Amino Acid Sequence, Base Sequence, genetics: Body Weight, genetics: Energy Metabolism, Genetic Screening, genetics: Homeostasis, Humans, metabolism: Hypothalamus, Immunohistochemistry, Molecular Sequence Data, genetics: Mutation, Missense, genetics: Obesity, Sequence Alignment, Sequence Analysis, DNA, genetics: beta-MSH",

author = "Heike Biebermann and Casta{\~n}eda, {Tamara R.} and {van Landeghem}, Frank and {von Deimling}, Andreas and Frederike Escher and Georg Brabant and Johannes Hebebrand and Anke Hinney and Tsch{\"o}p, {Matthias H.} and Annette Gr{\"u}ters and Heiko Krude",

year = "2006",

month = feb,

doi = "10.1016/j.cmet.2006.01.007",

language = "English",

volume = "3",

pages = "141--146",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "2",

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T1 - A role for β-melanocyte-stimulating hormone in human body-weight regulation

AU - Biebermann, Heike

AU - Castañeda, Tamara R.

AU - van Landeghem, Frank

AU - von Deimling, Andreas

AU - Escher, Frederike

AU - Brabant, Georg

AU - Hebebrand, Johannes

AU - Hinney, Anke

AU - Tschöp, Matthias H.

AU - Grüters, Annette

AU - Krude, Heiko

PY - 2006/2

Y1 - 2006/2

N2 - Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on α-melanocyte-stimulating hormone (α-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide β-MSH (Y5C-β-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide β-MSH plays a critical role in the hypothalamic control of body weight in humans. © 2006 Elsevier Inc.

AB - Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on α-melanocyte-stimulating hormone (α-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide β-MSH (Y5C-β-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide β-MSH plays a critical role in the hypothalamic control of body weight in humans. © 2006 Elsevier Inc.

KW - Amino Acid Sequence

KW - Base Sequence

KW - genetics: Body Weight

KW - genetics: Energy Metabolism

KW - Genetic Screening

KW - genetics: Homeostasis

KW - Humans

KW - metabolism: Hypothalamus

KW - Immunohistochemistry

KW - Molecular Sequence Data

KW - genetics: Mutation, Missense

KW - genetics: Obesity

KW - Sequence Alignment

KW - Sequence Analysis, DNA

KW - genetics: beta-MSH

U2 - 10.1016/j.cmet.2006.01.007

DO - 10.1016/j.cmet.2006.01.007

M3 - Article

SN - 1550-4131

VL - 3

SP - 141

EP - 146

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

A role for β-melanocyte-stimulating hormone in human body-weight regulation

Abstract

Keywords

UN SDGs

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