A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.

Ahmet Acar; Bruno M Simões; Robert B Clarke; Keith Brennan

doi:10.1155/2016/2498764

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.

Ahmet Acar, Bruno M Simões, Robert B Clarke, Keith Brennan

Research output: Contribution to journal › Article › peer-review

Abstract

Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.

Original language	English
Journal	Stem cells international
Volume	2016
DOIs	https://doi.org/10.1155/2016/2498764
Publication status	Published - 2016

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10.1155/2016/2498764

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title = "A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.",

abstract = "Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.",

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AU - Simões, Bruno M

AU - Clarke, Robert B

AU - Brennan, Keith

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AB - Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.

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DO - 10.1155/2016/2498764

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C2 - 26880941

VL - 2016

JO - Stem cells international

JF - Stem cells international

ER -

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.

Abstract

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