A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape

L. J. Leamy, C. P. Klingenberg, E. Sherratt, J. B. Wolf, J. M. Cheverud

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F3 population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting. © 2008 Macmillan Publishers Limited All rights reserved.
    Original languageEnglish
    Pages (from-to)518-526
    Number of pages8
    JournalHeredity
    Volume101
    Issue number6
    DOIs
    Publication statusPublished - Dec 2008

    Keywords

    • Geometric morphometrics
    • Imprinting QTL
    • Mandible size and shape
    • Maternal genetic effects
    • Mouse

    Fingerprint

    Dive into the research topics of 'A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape'. Together they form a unique fingerprint.

    Cite this