A selective Review and Virtual Screening Analysis of Natural Product Inhibitors of the NLRP3 Inflammasome

Sherihan El Sayed, Sally Freeman, Richard A. Bryce

Research output: Contribution to journalReview articlepeer-review

Abstract

The NLRP3 inflammasome is currently an exciting target for drug discovery due to its role in various inflammatory diseases; however, to date, no NLRP3 inhibitors have reached the clinic. Several studies have used natural products as hit compounds to facilitate the design of nov- el selective NLRP3 inhibitors. Here, we review selected natural products reported in the literature as NLRP3 inhibitors, with a particular focus on those targeting gout. To complement this survey, we also report a virtual screen of the ZINC20 natural product database, predicting favored chemi- cal features that can aid in the design of novel small molecule NLRP3 inhibitors.
Original languageEnglish
JournalMolecules
Early online date21 Sept 2022
DOIs
Publication statusPublished - 21 Sept 2022

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