A selenocysteine tRNA and SECIS element in Plasmodium falciparum

Tobias Mourier; Arnab Pain; Bart Barrell; Sam Griffiths-Jones

doi:10.1261/rna.7185605

A selenocysteine tRNA and SECIS element in Plasmodium falciparum

Tobias Mourier, Arnab Pain, Bart Barrell, Sam Griffiths-Jones

Research output: Contribution to journal › Article › peer-review

Abstract

The molecular machinery for incorporating selenocysteine into proteins is present in both prokaryotes and eukaryotes. Although selenocysteine insertion has been reported in animals, plants, and protozoans, known eukaryotic selenocysteine tRNA sequences and selenocysteine insertion sequences are limited to animals and plants. Here we present clear indications of the presence of selenocysteine-tRNA and a selenocysteine insertion sequence in Plasmodium falciparum. To our knowledge, this is the first report of an identification of protozoan selenocysteine insertion machinery at the sequence level.

Original language	English
Pages (from-to)	119-122
Number of pages	3
Journal	RNA
Volume	11
Issue number	2
DOIs	https://doi.org/10.1261/rna.7185605
Publication status	Published - Feb 2005

Keywords

Apicomplexa
Malaria
Plasmodium
SECIS element
Selenocysteine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1261/rna.7185605

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title = "A selenocysteine tRNA and SECIS element in Plasmodium falciparum",

abstract = "The molecular machinery for incorporating selenocysteine into proteins is present in both prokaryotes and eukaryotes. Although selenocysteine insertion has been reported in animals, plants, and protozoans, known eukaryotic selenocysteine tRNA sequences and selenocysteine insertion sequences are limited to animals and plants. Here we present clear indications of the presence of selenocysteine-tRNA and a selenocysteine insertion sequence in Plasmodium falciparum. To our knowledge, this is the first report of an identification of protozoan selenocysteine insertion machinery at the sequence level.",

keywords = "Apicomplexa, Malaria, Plasmodium, SECIS element, Selenocysteine",

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doi = "10.1261/rna.7185605",

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T1 - A selenocysteine tRNA and SECIS element in Plasmodium falciparum

AU - Mourier, Tobias

AU - Pain, Arnab

AU - Barrell, Bart

AU - Griffiths-Jones, Sam

PY - 2005/2

Y1 - 2005/2

N2 - The molecular machinery for incorporating selenocysteine into proteins is present in both prokaryotes and eukaryotes. Although selenocysteine insertion has been reported in animals, plants, and protozoans, known eukaryotic selenocysteine tRNA sequences and selenocysteine insertion sequences are limited to animals and plants. Here we present clear indications of the presence of selenocysteine-tRNA and a selenocysteine insertion sequence in Plasmodium falciparum. To our knowledge, this is the first report of an identification of protozoan selenocysteine insertion machinery at the sequence level.

AB - The molecular machinery for incorporating selenocysteine into proteins is present in both prokaryotes and eukaryotes. Although selenocysteine insertion has been reported in animals, plants, and protozoans, known eukaryotic selenocysteine tRNA sequences and selenocysteine insertion sequences are limited to animals and plants. Here we present clear indications of the presence of selenocysteine-tRNA and a selenocysteine insertion sequence in Plasmodium falciparum. To our knowledge, this is the first report of an identification of protozoan selenocysteine insertion machinery at the sequence level.

KW - Apicomplexa

KW - Malaria

KW - Plasmodium

KW - SECIS element

KW - Selenocysteine

U2 - 10.1261/rna.7185605

DO - 10.1261/rna.7185605

M3 - Article

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SN - 1355-8382

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SP - 119

EP - 122

JO - RNA

JF - RNA

IS - 2

ER -

A selenocysteine tRNA and SECIS element in Plasmodium falciparum

Abstract

Keywords

UN SDGs

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