A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro

L.R. Mikhailova, L.A. Baltina Jr, L.A. Baltina, R.M. Kondratenko, S.A. Nepogodiev, R.A. Field, O. Kunert, M.C. Yin

Research output: Contribution to journalArticlepeer-review

Abstract

A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.
Original languageRussian
Pages (from-to)686-695
Number of pages10
JournalBioorganicheskaia khimiia
Publication statusPublished - 2009

Keywords

  • Glycyrrhizic Acid
  • Glycyrrhetinic Acid
  • Licorice root

Research Beacons, Institutes and Platforms

  • Manchester Institute of Biotechnology

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