A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow

Robert F. Wynn; Claire A. Hart; Carla Corradi-Perini; Liam O'Neill; Caroline A. Evans; J. Ed Wraith; Leslie J. Fairbairn; Ilaria Bellantuono

doi:10.1182/blood-2004-02-0526

A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow

Robert F. Wynn, Claire A. Hart, Carla Corradi-Perini, Liam O'Neill, Caroline A. Evans, J. Ed Wraith, Leslie J. Fairbairn, Ilaria Bellantuono

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. © 2004 by The American Society of Hematology.

Original language	English
Pages (from-to)	2643-2645
Number of pages	2
Journal	Blood
Volume	104
Issue number	9
DOIs	https://doi.org/10.1182/blood-2004-02-0526
Publication status	Published - 1 Nov 2004

Keywords

physiology: Bone Marrow
Cells, Cultured
physiology: Chemokines, CXC
Chemotaxis
Coculture Techniques
Humans
metabolism: Mesenchymal Stem Cells
biosynthesis: Receptors, CXCR4
Research Support, Non-U.S. Gov't
physiology: Stromal Cells

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10.1182/blood-2004-02-0526

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@article{96c4953d15014d4c918c88acc0fd5773,

title = "A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow",

abstract = "Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. {\textcopyright} 2004 by The American Society of Hematology.",

keywords = "physiology: Bone Marrow, Cells, Cultured, physiology: Chemokines, CXC, Chemotaxis, Coculture Techniques, Humans, metabolism: Mesenchymal Stem Cells, biosynthesis: Receptors, CXCR4, Research Support, Non-U.S. Gov't, physiology: Stromal Cells",

author = "Wynn, {Robert F.} and Hart, {Claire A.} and Carla Corradi-Perini and Liam O'Neill and Evans, {Caroline A.} and Wraith, {J. Ed} and Fairbairn, {Leslie J.} and Ilaria Bellantuono",

year = "2004",

month = nov,

day = "1",

doi = "10.1182/blood-2004-02-0526",

language = "English",

volume = "104",

pages = "2643--2645",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "9",

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TY - JOUR

T1 - A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow

AU - Wynn, Robert F.

AU - Hart, Claire A.

AU - Corradi-Perini, Carla

AU - O'Neill, Liam

AU - Evans, Caroline A.

AU - Wraith, J. Ed

AU - Fairbairn, Leslie J.

AU - Bellantuono, Ilaria

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. © 2004 by The American Society of Hematology.

AB - Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. © 2004 by The American Society of Hematology.

KW - physiology: Bone Marrow

KW - Cells, Cultured

KW - physiology: Chemokines, CXC

KW - Chemotaxis

KW - Coculture Techniques

KW - Humans

KW - metabolism: Mesenchymal Stem Cells

KW - biosynthesis: Receptors, CXCR4

KW - Research Support, Non-U.S. Gov't

KW - physiology: Stromal Cells

U2 - 10.1182/blood-2004-02-0526

DO - 10.1182/blood-2004-02-0526

M3 - Article

VL - 104

SP - 2643

EP - 2645

JO - Blood

JF - Blood

SN - 0006-4971

IS - 9

ER -

A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow

Abstract

Keywords

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