TY - JOUR
T1 - A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow
AU - Wynn, Robert F.
AU - Hart, Claire A.
AU - Corradi-Perini, Carla
AU - O'Neill, Liam
AU - Evans, Caroline A.
AU - Wraith, J. Ed
AU - Fairbairn, Leslie J.
AU - Bellantuono, Ilaria
PY - 2004/11/1
Y1 - 2004/11/1
N2 - Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. © 2004 by The American Society of Hematology.
AB - Homing of bone marrow stromal cells (MSCs) to bone and bone marrow after transplantation, important for the correction of conditions such as metabolic storage disorders, can occur but with poor efficiency. Substantial improvements in engraftment will be required in order to derive a clinical benefit from MSC transplantation. Chemokines are the most important factors controlling cellular migration. Stromal-derived factor-1 (SDF-1) has been shown to be critical in promoting the migration of cells to the bone marrow, via its specific receptor CXCR4. The aim of our study was to investigate CXCR4 expression on MSCs and its role in mediating migration to bone marrow. We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow. © 2004 by The American Society of Hematology.
KW - physiology: Bone Marrow
KW - Cells, Cultured
KW - physiology: Chemokines, CXC
KW - Chemotaxis
KW - Coculture Techniques
KW - Humans
KW - metabolism: Mesenchymal Stem Cells
KW - biosynthesis: Receptors, CXCR4
KW - Research Support, Non-U.S. Gov't
KW - physiology: Stromal Cells
UR - https://www.scopus.com/pages/publications/7244224904
U2 - 10.1182/blood-2004-02-0526
DO - 10.1182/blood-2004-02-0526
M3 - Article
SN - 0006-4971
VL - 104
SP - 2643
EP - 2645
JO - Blood
JF - Blood
IS - 9
ER -