A stem cell molecutar signature

Natalia B. Ivanova; John T. Dimos; Christoph Schaniel; Jason A. Hackney; Kateri A. Moore; Ihor R. Lemischka

doi:10.1126/science.1073823

A stem cell molecutar signature

Natalia B. Ivanova, John T. Dimos, Christoph Schaniel, Jason A. Hackney, Kateri A. Moore, Ihor R. Lemischka

Research output: Contribution to journal › Article › peer-review

Abstract

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

Original language	English
Pages (from-to)	601-604
Number of pages	3
Journal	Science
Volume	298
Issue number	5593
DOIs	https://doi.org/10.1126/science.1073823
Publication status	Published - 18 Oct 2002

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title = "A stem cell molecutar signature",

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AU - Ivanova, Natalia B.

AU - Dimos, John T.

AU - Schaniel, Christoph

AU - Hackney, Jason A.

AU - Moore, Kateri A.

AU - Lemischka, Ihor R.

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N2 - Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

AB - Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

U2 - 10.1126/science.1073823

DO - 10.1126/science.1073823

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VL - 298

SP - 601

EP - 604

JO - Science

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ER -

A stem cell molecutar signature

Abstract

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