A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases

Simon Willies; James Galman; Iustina Slabu; Nicholas Turner

doi:10.1098/rsta.2015.0084

A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases

Simon Willies, James Galman, Iustina Slabu, Nicholas Turner

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Abstract

A novel solid-phase screening assay was developed for colonies expressing both (R)- and (S)-selective ω-aminotransferases. This high-throughput assay can be used to screen rapidly large variant libraries with enhanced substrate selectivity and enantioselectivities.

Original language	English
Journal	Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences
DOIs	https://doi.org/10.1098/rsta.2015.0084
Publication status	Published - 11 Jan 2016

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10.1098/rsta.2015.0084

Turner Revised PTA solid phase screening paper 1Accepted author manuscript, 2.3 MB

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title = "A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases",

abstract = "A novel solid-phase screening assay was developed for colonies expressing both (R)- and (S)-selective ω-aminotransferases. This high-throughput assay can be used to screen rapidly large variant libraries with enhanced substrate selectivity and enantioselectivities.",

author = "Simon Willies and James Galman and Iustina Slabu and Nicholas Turner",

year = "2016",

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doi = "10.1098/rsta.2015.0084",

language = "English",

journal = "Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences",

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T1 - A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases

AU - Willies, Simon

AU - Galman, James

AU - Slabu, Iustina

AU - Turner, Nicholas

PY - 2016/1/11

Y1 - 2016/1/11

N2 - A novel solid-phase screening assay was developed for colonies expressing both (R)- and (S)-selective ω-aminotransferases. This high-throughput assay can be used to screen rapidly large variant libraries with enhanced substrate selectivity and enantioselectivities.

AB - A novel solid-phase screening assay was developed for colonies expressing both (R)- and (S)-selective ω-aminotransferases. This high-throughput assay can be used to screen rapidly large variant libraries with enhanced substrate selectivity and enantioselectivities.

U2 - 10.1098/rsta.2015.0084

DO - 10.1098/rsta.2015.0084

M3 - Article

SN - 1471-2946

JO - Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences

JF - Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences

ER -

A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases

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