A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon

K. V. Poulton; L. J. Kennedy; J. Ross; W. Thomson; J. C. Mbanya; W. E R Ollier

doi:10.1046/j.1365-2370.1998.00114.x

A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon

K. V. Poulton, L. J. Kennedy, J. Ross, W. Thomson, J. C. Mbanya, W. E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.

Original language	English
Pages (from-to)	375-377
Number of pages	2
Journal	European Journal of Immunogenetics
Volume	25
Issue number	5
DOIs	https://doi.org/10.1046/j.1365-2370.1998.00114.x
Publication status	Published - 1998

Keywords

ACADEMIC JOURNAL PAPERS
ORIGINAL ARTICLES

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10.1046/j.1365-2370.1998.00114.x

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title = "A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon",

abstract = "Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.",

keywords = "ACADEMIC JOURNAL PAPERS, ORIGINAL ARTICLES",

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doi = "10.1046/j.1365-2370.1998.00114.x",

language = "English",

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T1 - A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon

AU - Poulton, K. V.

AU - Kennedy, L. J.

AU - Ross, J.

AU - Thomson, W.

AU - Mbanya, J. C.

AU - Ollier, W. E R

N1 - UI - 99022503 LA - eng RN - 0 (HLA-DP Antigens) RN - 0 (HLA-DPB1) PT - Journal Article DA - 19990121 IS - 0960-7420 SB - IM CY - ENGLAND

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N2 - Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.

AB - Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.

KW - ACADEMIC JOURNAL PAPERS

KW - ORIGINAL ARTICLES

UR - https://www.scopus.com/pages/publications/0031659653

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DO - 10.1046/j.1365-2370.1998.00114.x

M3 - Article

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JO - European Journal of Immunogenetics

JF - European Journal of Immunogenetics

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ER -

A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon

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