A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

D. Gibson; S.W. Homans; R.A. Field

doi:10.1016/j.tetasy.2009.02.021

A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

D. Gibson, S.W. Homans, R.A. Field

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

Original language	Undefined
Journal	Tetrahedron Asymmetry
DOIs	https://doi.org/10.1016/j.tetasy.2009.02.021
Publication status	Published - 2009

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Manchester Institute of Biotechnology

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10.1016/j.tetasy.2009.02.021

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title = "A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin",

abstract = "Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.",

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AU - Gibson, D.

AU - Homans, S.W.

AU - Field, R.A.

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N2 - Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

AB - Functionalised carbohydrates for incorporation into multivalent ligands for the Escherichia coli 0157 verotoxin are highly desirable. Here, we report the synthesis of a sugar aminoacid based on the known Gal-α-1,4-Gal ligand for verotoxin in eight steps and in ∼10% overall yield.

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DO - 10.1016/j.tetasy.2009.02.021

M3 - Article

SN - 0957-4166

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

ER -

A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

Abstract

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