A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

Gavin J. Miller; John M. Gardiner

doi:10.1016/j.tetlet.2011.04.047

A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

Research output: Contribution to journal › Article › peer-review

Abstract

Divergent synthesis of two novel C-glycosidic multivalent mannosides derived from a common trivalent C-mannosyl carboxylate-terminated intermediate is described. This illustrates synthesis of multivalent C-glycosidic architectures bearing variable extended functionalized tethers. One such tether incorporates an embedded fluorescent unit providing a C-mannosyl multivalent epitope offering potential applications through further conjugation or immobilization. © 2011 Published by Elsevier Ltd.

Original language	English
Pages (from-to)	3216-3218
Number of pages	2
Journal	Tetrahedron Letters
Volume	52
Issue number	25
DOIs	https://doi.org/10.1016/j.tetlet.2011.04.047
Publication status	Published - 22 Jun 2011

Keywords

C-Glycosides
Carbohydrates
Glycobiology
Glycoconjugation
Multivalency

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10.1016/j.tetlet.2011.04.047

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abstract = "Divergent synthesis of two novel C-glycosidic multivalent mannosides derived from a common trivalent C-mannosyl carboxylate-terminated intermediate is described. This illustrates synthesis of multivalent C-glycosidic architectures bearing variable extended functionalized tethers. One such tether incorporates an embedded fluorescent unit providing a C-mannosyl multivalent epitope offering potential applications through further conjugation or immobilization. {\textcopyright} 2011 Published by Elsevier Ltd.",

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AU - Gardiner, John M.

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AB - Divergent synthesis of two novel C-glycosidic multivalent mannosides derived from a common trivalent C-mannosyl carboxylate-terminated intermediate is described. This illustrates synthesis of multivalent C-glycosidic architectures bearing variable extended functionalized tethers. One such tether incorporates an embedded fluorescent unit providing a C-mannosyl multivalent epitope offering potential applications through further conjugation or immobilization. © 2011 Published by Elsevier Ltd.

KW - C-Glycosides

KW - Carbohydrates

KW - Glycobiology

KW - Glycoconjugation

KW - Multivalency

U2 - 10.1016/j.tetlet.2011.04.047

DO - 10.1016/j.tetlet.2011.04.047

M3 - Article

SN - 1873-3581

VL - 52

SP - 3216

EP - 3218

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 25

ER -

A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

Abstract

Keywords

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