A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal : GPI anchor side-chain α-galactosyltransferases

J.R. Brown; T.K. Smith; M.A.J. Ferguson; R.A. Field

doi:10.1016/S0960-894X(98)00359-X

A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal : GPI anchor side-chain α-galactosyltransferases

J.R. Brown, T.K. Smith, M.A.J. Ferguson, R.A. Field

Research output: Contribution to journal › Article › peer-review

Abstract

A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-α-1,2-Gal linkage.

Original language	Undefined
Pages (from-to)	2051-2054
Journal	Bioorganic and Medicinal Chemistry Letters
DOIs	https://doi.org/10.1016/S0960-894X(98)00359-X
Publication status	Published - 1998

Keywords

Glycosylphosphatidylinositols
Mutation
Proteins GPI-APs Prominence percentile: 79.610

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1016/S0960-894X(98)00359-X

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abstract = "A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-α-1,2-Gal linkage.",

keywords = "Glycosylphosphatidylinositols, Mutation, Proteins GPI-APs Prominence percentile: 79.610",

author = "J.R. Brown and T.K. Smith and M.A.J. Ferguson and R.A. Field",

year = "1998",

doi = "10.1016/S0960-894X(98)00359-X",

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T1 - A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal : GPI anchor side-chain α-galactosyltransferases

AU - Brown, J.R.

AU - Smith, T.K.

AU - Ferguson, M.A.J.

AU - Field, R.A.

PY - 1998

Y1 - 1998

N2 - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-α-1,2-Gal linkage.

AB - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-α-l,3(Man-α-1,6)-Man-α-O-octyl (1), serves as a substrate for two T. brucei α-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-α-1,2-Gal linkage.

KW - Glycosylphosphatidylinositols

KW - Mutation

KW - Proteins GPI-APs Prominence percentile: 79.610

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0032483111&partnerID=MN8TOARS

U2 - 10.1016/S0960-894X(98)00359-X

DO - 10.1016/S0960-894X(98)00359-X

M3 - Article

SN - 0960-894X

SP - 2051

EP - 2054

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

ER -

A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal : GPI anchor side-chain α-galactosyltransferases

Abstract

Keywords

Research Beacons, Institutes and Platforms

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