A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21

R. B. Warren; R. L. Smith; E. Flynn; J. Bowes; S. Eyre; J. Worthington; A. Barton; C. E M Griffiths

doi:10.1111/j.1365-2133.2011.10237.x

A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21

R. B. Warren, R. L. Smith, E. Flynn, J. Bowes, S. Eyre, J. Worthington, A. Barton, C. E M Griffiths

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Abstract

Background Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression. Objectives The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis. Methods Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom® MassArray™ iPLEX Gold platform. Results We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10-4; rs2069778, genotypic P = 7·86 × 10-4) region. Conclusions The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.

Original language	English
Pages (from-to)	660-664
Number of pages	4
Journal	British Journal of Dermatology
Volume	164
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2133.2011.10237.x
Publication status	Published - Mar 2011

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title = "A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21",

abstract = "Background Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression. Objectives The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis. Methods Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom{\textregistered} MassArray{\texttrademark} iPLEX Gold platform. Results We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10-4; rs2069778, genotypic P = 7·86 × 10-4) region. Conclusions The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases. {\textcopyright} 2011 The Authors. BJD {\textcopyright} 2011 British Association of Dermatologists.",

author = "Warren, {R. B.} and Smith, {R. L.} and E. Flynn and J. Bowes and S. Eyre and J. Worthington and A. Barton and Griffiths, {C. E M}",

year = "2011",

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doi = "10.1111/j.1365-2133.2011.10237.x",

language = "English",

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T1 - A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21

AU - Warren, R. B.

AU - Smith, R. L.

AU - Flynn, E.

AU - Bowes, J.

AU - Eyre, S.

AU - Worthington, J.

AU - Barton, A.

AU - Griffiths, C. E M

PY - 2011/3

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N2 - Background Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression. Objectives The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis. Methods Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom® MassArray™ iPLEX Gold platform. Results We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10-4; rs2069778, genotypic P = 7·86 × 10-4) region. Conclusions The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.

AB - Background Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression. Objectives The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis. Methods Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom® MassArray™ iPLEX Gold platform. Results We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10-4; rs2069778, genotypic P = 7·86 × 10-4) region. Conclusions The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.

U2 - 10.1111/j.1365-2133.2011.10237.x

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A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21

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