A systematic review of adherence-enhancing interventions in adolescents taking long-term medicines

Nde-Eshimuni M Salema, Rachel A Elliott, Cris Glazebrook

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To assess the effectiveness of adherence-enhancing interventions (AEIs) aimed at adolescents (10-19-year-olds).

METHODS: An extensive search of seven bibliographic databases was conducted at the end of 2009 to identify comparative studies evaluating AEIs targeting adolescents. Data describing study characteristics and intervention effects on adherence to medicines or health outcomes were extracted and summarized using qualitative and quantitative methods.

RESULTS: A total of 17 AEIs were identified: 12 studies (70%) were conducted in the United States, 10 (59%) included adolescents with type 1 diabetes mellitus, and 14 (82%) considered the developmental tasks of adolescence. In all, 12 AEIs successfully improved outcome measures. Features of successful interventions included targeting AEIs to a narrow age range, including family in type 1 diabetes mellitus management, and improving access to care. Poor quality and underpowered studies limit the inferences drawn from this review.

CONCLUSIONS: More diverse and robust studies are needed to identify strategies to help adolescents manage medicines.

Original languageEnglish
Pages (from-to)455-66
Number of pages12
JournalJournal of Adolescent Health
Volume49
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Adolescent
  • Adolescent Behavior
  • Attitude to Health
  • Child
  • Child Behavior
  • Chronic Disease
  • Diabetes Mellitus
  • Evidence-Based Medicine
  • Guideline Adherence
  • Humans
  • Hypoglycemic Agents
  • Medication Adherence
  • Patient Education as Topic
  • Quality Assurance, Health Care
  • Reminder Systems
  • Socioeconomic Factors
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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