A Systematic Review of the Therapeutic Outcome of Mucormycosis

L Shamithra M Sigera, David W Denning

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Mucormycosis is a potentially lethal mycosis. We reviewed peer-reviewed publications on mucormycosis to assess therapeutic outcomes. Methods: A systematic literature search using the Ovid MEDLINE and EMBASE databases identified manuscripts describing human mucormycosis diagnosed according to European Organization for Research and Treatment of Cancer and the Mycoses Study Group criteria with therapeutic outcomes published from 2000 to 2022. Results: In 126 articles, 10 335 patients were described, most from Asia (n = 6632, 66%). Diabetes was the most frequent underlying disease (n = 6188, 60%); 222 (2.1%) patients had no underlying diseases. The dominant clinical form was rhino-orbitocerebral (n = 7159, 69.3%), followed by pulmonary (n = 1062, 10.3%). Of 5364 patients with outcome data, amphotericin B monotherapy (n = 3749, mortality 31.5%) was most frequent, followed by amphotericin B + azole (n = 843, mortality 6.6%; P <. 0001), amphotericin B followed by azole (n = 357, mortality 13.7%; P <. 0001), posaconazole only (n = 250, mortality 17.2%; P <. 0001), and isavuconazole only (n = 65, mortality 24.6%; P =. 24). Duration and dose of antifungals varied widely. Documented outcomes from surgical resections in 149 patients found that 47 of 125 died (37.6%), compared with 16 of 24 (66.7%) patients who did not undergo surgery (P =. 008). Conclusions: Mucormycosis is more frequently reported in Asia than in Europe and is often linked to diabetes. Antifungal therapy, usually with surgery, is frequently effective for mucormycosis.

Original languageEnglish
Article numberofad704
JournalOpen Forum Infectious Diseases
Volume11
Issue number1
Early online date30 Dec 2023
DOIs
Publication statusPublished - 2 Jan 2024

Keywords

  • Absidia
  • Apophysomyces
  • Lichtheimia
  • Mucor
  • Rhizomucor
  • Rhizopus

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