Abstract
Introduction
Non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly used over the counter analgesics for the management of post‐operative pain following dental surgery, including dental implant placement. NSAIDs work through inhibition of the cyclo‐oxygenase (COX) enzyme, in particular the isoform COX‐2. COX‐2 has been shown to induce new bone formation with upregulation of COX‐2 demonstrated following bony fractures. The aim of this systematic review was to determine if NSAID use affects bone healing and osseointegration following dental implant placement.
Methods
Electronic databases (Medline and Embase) were searched in addition to hand searches from reference lists of selected papers. Only randomised control trials were included in this review.
Results
Three studies were included and data provided on bone healing and osseointegration following dental implant surgery (with and without NSAID use) were analysed. The Cochrane risk of bias tool (2.0) were used to assess risk of bias. Two randomised control trials were conducted on animal subjects and one on human participants. One animal study reported significantly reduced bone healing around dental implants following the use of prolonged subcutaneous NSAIDs. No other studies reported any significant findings. There was considerable heterogeneity between included studies.
Conclusion
There is limited evidence exploring the relationship of NSAIDs and dental implant osseointegration and bone healing to draw definitive conclusions. Further research is required in this area.
Non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly used over the counter analgesics for the management of post‐operative pain following dental surgery, including dental implant placement. NSAIDs work through inhibition of the cyclo‐oxygenase (COX) enzyme, in particular the isoform COX‐2. COX‐2 has been shown to induce new bone formation with upregulation of COX‐2 demonstrated following bony fractures. The aim of this systematic review was to determine if NSAID use affects bone healing and osseointegration following dental implant placement.
Methods
Electronic databases (Medline and Embase) were searched in addition to hand searches from reference lists of selected papers. Only randomised control trials were included in this review.
Results
Three studies were included and data provided on bone healing and osseointegration following dental implant surgery (with and without NSAID use) were analysed. The Cochrane risk of bias tool (2.0) were used to assess risk of bias. Two randomised control trials were conducted on animal subjects and one on human participants. One animal study reported significantly reduced bone healing around dental implants following the use of prolonged subcutaneous NSAIDs. No other studies reported any significant findings. There was considerable heterogeneity between included studies.
Conclusion
There is limited evidence exploring the relationship of NSAIDs and dental implant osseointegration and bone healing to draw definitive conclusions. Further research is required in this area.
| Original language | English |
|---|---|
| Journal | Oral Surgery |
| Volume | 13 |
| Issue number | 1 |
| Early online date | 19 Aug 2019 |
| DOIs | |
| Publication status | Published - 8 Jan 2020 |