Abstract
Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a β-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none. © 1989.
Original language | English |
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Pages (from-to) | 403-407 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 257 |
Issue number | 2 |
DOIs | |
Publication status | Published - 6 Nov 1989 |
Keywords
- Electrostatic modeling
- Histidine residue
- pH dependence
- Picornavirus
- Viral uncoating