A theoretical study of the acidification of the rhinovirus capsid

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    Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a β-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none. © 1989.
    Original languageEnglish
    Pages (from-to)403-407
    Number of pages4
    JournalFEBS Letters
    Issue number2
    Publication statusPublished - 6 Nov 1989


    • Electrostatic modeling
    • Histidine residue
    • pH dependence
    • Picornavirus
    • Viral uncoating


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