A theoretical study of the acidification of the rhinovirus capsid

J. Warwicker

doi:10.1016/0014-5793(89)81582-0

A theoretical study of the acidification of the rhinovirus capsid

Research output: Contribution to journal › Article › peer-review

Abstract

Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a β-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none. © 1989.

Original language	English
Pages (from-to)	403-407
Number of pages	4
Journal	FEBS Letters
Volume	257
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)81582-0
Publication status	Published - 6 Nov 1989

Keywords

Electrostatic modeling
Histidine residue
pH dependence
Picornavirus
Viral uncoating

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-5793(89)81582-0

Cite this

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abstract = "Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a β-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none. {\textcopyright} 1989.",

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AB - Electrostatic calculations for human rhinovirus 14 indicate that histidine-base residue pairs in the region of a β-strand interaction between pentamers may be involved in a pH-induced process that leads to the release of viral RNA. Other picornavirus sequences are examined for these residue pairs, a subset of which is present in enteroviruses. Foot and mouth disease virus possesses one of the residue pairs, and cardioviruses, which undergo a separate pH and halide ion-induced capsid dissociation, possess none. © 1989.

KW - Electrostatic modeling

KW - Histidine residue

KW - pH dependence

KW - Picornavirus

KW - Viral uncoating

U2 - 10.1016/0014-5793(89)81582-0

DO - 10.1016/0014-5793(89)81582-0

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SP - 403

EP - 407

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

A theoretical study of the acidification of the rhinovirus capsid

Abstract

Keywords

UN SDGs

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