@article{c33d81fd4abb420b9ace25693840721d,
title = "A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia",
abstract = "Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17-gene LSC score, LSC-17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three-gene expression signature (LSC-3, derived from the LSC-17 score) as an independent and robust prognostic factor for leukaemia-free and overall survival in CMML. We propose that LSC-3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.",
keywords = "Humans, Leukemia, Myelomonocytic, Chronic/diagnosis, Prognosis, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Stem Cells",
author = "Yu-Hung Wang and Chi-Yuan Yao and Chien-Chin Lin and Kristian Gurashi and Amaral, {Fabio M R} and Hasse Bossenbroek and Andres Jerez and Somervaille, {Tim C P} and Moritz Binder and Patnaik, {Mrinal M} and Hsin-An Hou and Wen-Chien Chou and Kiran Batta and Wiseman, {Daniel H} and Hwei-Fang Tien",
note = "Funding Information: The work was supported by grants from Ministry of Science and Technology, Taiwan, project numbers: MOST 109‐2314‐B‐002‐221, 109‐2314‐B‐002‐222; Taiwan Ministry of Health and Welfare, project number: MOHW109‐TDU‐B‐211‐134 009. The Manchester CMML Research Group is funded by a grant from The Oglesby Charitable Trust. Fabio M. R. Amaral and Tim C. P. Somervaille are funded by Cancer Research UK grant number C5759/A27412. Funding Information: We acknowledge the service provided by Department of Laboratory Medicine, Department of Medical Research, and Division of Haematology, Department of Internal Medicine, National Taiwan University Hospital. Publisher Copyright: {\textcopyright} 2023 British Society for Haematology and John Wiley & Sons Ltd.",
year = "2023",
month = apr,
day = "1",
doi = "10.1111/bjh.18681",
language = "English",
volume = "201",
pages = "302--307",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons Ltd",
number = "2",
}
