The need for integrated sensing and communication (ISAC) services has significantly increased in the last few years. This integration imposes serious challenges such as joint system design, resource allocation, optimization, and analysis. Since sensing and telecommunication systems have different approaches for performance evaluation, introducing a unified performance measure which provides a perception about the quality of sensing and telecommunication is very beneficial. To this end, this paper provides performance analysis for ISAC systems based on the information theoretical framework of the Kullback-Leibler divergence (KLD). The considered system model consists of a multiple-input-multiple-output (MIMO) base-station (BS) providing ISAC services to multiple communication user equipments (CUEs) and targets (or sensing-served users). The KLD framework allows for a unified evaluation of the error rate performance of CUEs, and the detection performance of the targets. The relation between the detection capability for the targets and error rate of CUEs on one hand, and the proposed KLD on the other hand is illustrated analytically. Theoretical results corroborated by simulations show that the derived KLD is very accurate and can perfectly characterize both subsystems, namely the communication and radar subsystems.