A uniform system for microRNA annotation

Victor Ambros; Bonnie Bartel; David P. Bartel; Christopher B. Burge; James C. Carrington; Xuemei Chen; Gideon Dreyfuss; Sean R. Eddy; Sam Griffiths-Jones; Mhairi Marshall; Marjori Matzke; Gary Ruvkun; Thomas Tuschl

doi:10.1261/rna.2183803

A uniform system for microRNA annotation

Victor Ambros, Bonnie Bartel, David P. Bartel, Christopher B. Burge, James C. Carrington, Xuemei Chen, Gideon Dreyfuss, Sean R. Eddy, Sam Griffiths-Jones, Mhairi Marshall, Marjori Matzke, Gary Ruvkun, Thomas Tuschl

Research output: Contribution to journal › Article › peer-review

Abstract

MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.

Original language	English
Pages (from-to)	277-279
Number of pages	2
Journal	RNA
Volume	9
Issue number	3
DOIs	https://doi.org/10.1261/rna.2183803
Publication status	Published - 1 Mar 2003

Keywords

Dicer
Genome annotation
MicroRNA
Noncoding RNA
Rfam

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10.1261/rna.2183803

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title = "A uniform system for microRNA annotation",

abstract = "MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.",

keywords = "Dicer, Genome annotation, MicroRNA, Noncoding RNA, Rfam",

author = "Victor Ambros and Bonnie Bartel and Bartel, {David P.} and Burge, {Christopher B.} and Carrington, {James C.} and Xuemei Chen and Gideon Dreyfuss and Eddy, {Sean R.} and Sam Griffiths-Jones and Mhairi Marshall and Marjori Matzke and Gary Ruvkun and Thomas Tuschl",

year = "2003",

month = mar,

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doi = "10.1261/rna.2183803",

language = "English",

volume = "9",

pages = "277--279",

journal = "RNA",

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TY - JOUR

T1 - A uniform system for microRNA annotation

AU - Ambros, Victor

AU - Bartel, Bonnie

AU - Bartel, David P.

AU - Burge, Christopher B.

AU - Carrington, James C.

AU - Chen, Xuemei

AU - Dreyfuss, Gideon

AU - Eddy, Sean R.

AU - Griffiths-Jones, Sam

AU - Marshall, Mhairi

AU - Matzke, Marjori

AU - Ruvkun, Gary

AU - Tuschl, Thomas

PY - 2003/3/1

Y1 - 2003/3/1

N2 - MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.

AB - MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.

KW - Dicer

KW - Genome annotation

KW - MicroRNA

KW - Noncoding RNA

KW - Rfam

U2 - 10.1261/rna.2183803

DO - 10.1261/rna.2183803

M3 - Article

C2 - 12592000

SN - 1355-8382

VL - 9

SP - 277

EP - 279

JO - RNA

JF - RNA

IS - 3

ER -

A uniform system for microRNA annotation

Abstract

Keywords

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