A versatile sample injection system for miniaturised isotachophoresis devices

S. J. Baldock, P. R. Fielden, N. J. Goddard, H. R. Kretschmer, J. E. Prest, B. J Treves Brown

    Research output: Contribution to journalArticlepeer-review


    A variable-volume sample injector design is presented and evaluated for performing sample introduction protocols for carrying out miniaturised isotachophoresis (ITP) separations. The microdevice design features a wide bore sample loop channel connected to a narrower bore separation channel via a short injection channel angled at 45°. An additional side arm channel located at the injection point enabled a range of injection strategies, using a gravity-fed system, to be implemented and assessed. A model analyte was used to demonstrate the versatility of the injector design for low and high sample loading regimes suitable for concentrated and dilute sample solutions, respectively. © 2008 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)1440-1442
    Number of pages2
    JournalMicroelectronic Engineering
    Issue number5-6
    Publication statusPublished - May 2008


    • Chip technologies
    • Electroseparation
    • Injection methods
    • Instrumentation
    • Isotachophoresis
    • Microfluidic
    • Miniaturisation


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