A versatile sample injection system for miniaturised isotachophoresis devices

S. J. Baldock; P. R. Fielden; N. J. Goddard; H. R. Kretschmer; J. E. Prest; B. J Treves Brown

doi:10.1016/j.mee.2008.01.095

A versatile sample injection system for miniaturised isotachophoresis devices

S. J. Baldock, P. R. Fielden, N. J. Goddard, H. R. Kretschmer, J. E. Prest, B. J Treves Brown

Research output: Contribution to journal › Article › peer-review

Abstract

A variable-volume sample injector design is presented and evaluated for performing sample introduction protocols for carrying out miniaturised isotachophoresis (ITP) separations. The microdevice design features a wide bore sample loop channel connected to a narrower bore separation channel via a short injection channel angled at 45°. An additional side arm channel located at the injection point enabled a range of injection strategies, using a gravity-fed system, to be implemented and assessed. A model analyte was used to demonstrate the versatility of the injector design for low and high sample loading regimes suitable for concentrated and dilute sample solutions, respectively. © 2008 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	1440-1442
Number of pages	2
Journal	Microelectronic Engineering
Volume	85
Issue number	5-6
DOIs	https://doi.org/10.1016/j.mee.2008.01.095
Publication status	Published - May 2008

Keywords

Chip technologies
Electroseparation
Injection methods
Instrumentation
Isotachophoresis
Microfluidic
Miniaturisation

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10.1016/j.mee.2008.01.095

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title = "A versatile sample injection system for miniaturised isotachophoresis devices",

abstract = "A variable-volume sample injector design is presented and evaluated for performing sample introduction protocols for carrying out miniaturised isotachophoresis (ITP) separations. The microdevice design features a wide bore sample loop channel connected to a narrower bore separation channel via a short injection channel angled at 45°. An additional side arm channel located at the injection point enabled a range of injection strategies, using a gravity-fed system, to be implemented and assessed. A model analyte was used to demonstrate the versatility of the injector design for low and high sample loading regimes suitable for concentrated and dilute sample solutions, respectively. {\textcopyright} 2008 Elsevier B.V. All rights reserved.",

keywords = "Chip technologies, Electroseparation, Injection methods, Instrumentation, Isotachophoresis, Microfluidic, Miniaturisation",

author = "Baldock, {S. J.} and Fielden, {P. R.} and Goddard, {N. J.} and Kretschmer, {H. R.} and Prest, {J. E.} and Brown, {B. J Treves}",

year = "2008",

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doi = "10.1016/j.mee.2008.01.095",

language = "English",

volume = "85",

pages = "1440--1442",

journal = "Microelectronic Engineering",

issn = "0167-9317",

publisher = "Elsevier BV",

number = "5-6",

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TY - JOUR

T1 - A versatile sample injection system for miniaturised isotachophoresis devices

AU - Baldock, S. J.

AU - Fielden, P. R.

AU - Goddard, N. J.

AU - Kretschmer, H. R.

AU - Prest, J. E.

AU - Brown, B. J Treves

PY - 2008/5

Y1 - 2008/5

N2 - A variable-volume sample injector design is presented and evaluated for performing sample introduction protocols for carrying out miniaturised isotachophoresis (ITP) separations. The microdevice design features a wide bore sample loop channel connected to a narrower bore separation channel via a short injection channel angled at 45°. An additional side arm channel located at the injection point enabled a range of injection strategies, using a gravity-fed system, to be implemented and assessed. A model analyte was used to demonstrate the versatility of the injector design for low and high sample loading regimes suitable for concentrated and dilute sample solutions, respectively. © 2008 Elsevier B.V. All rights reserved.

AB - A variable-volume sample injector design is presented and evaluated for performing sample introduction protocols for carrying out miniaturised isotachophoresis (ITP) separations. The microdevice design features a wide bore sample loop channel connected to a narrower bore separation channel via a short injection channel angled at 45°. An additional side arm channel located at the injection point enabled a range of injection strategies, using a gravity-fed system, to be implemented and assessed. A model analyte was used to demonstrate the versatility of the injector design for low and high sample loading regimes suitable for concentrated and dilute sample solutions, respectively. © 2008 Elsevier B.V. All rights reserved.

KW - Chip technologies

KW - Electroseparation

KW - Injection methods

KW - Instrumentation

KW - Isotachophoresis

KW - Microfluidic

KW - Miniaturisation

U2 - 10.1016/j.mee.2008.01.095

DO - 10.1016/j.mee.2008.01.095

M3 - Article

SN - 0167-9317

VL - 85

SP - 1440

EP - 1442

JO - Microelectronic Engineering

JF - Microelectronic Engineering

IS - 5-6

ER -

A versatile sample injection system for miniaturised isotachophoresis devices

Abstract

Keywords

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