A view through the clouds of imprinting

Jason L. Burns, Dean A. Jackson, A. Bassim Hassan

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The purpose of this review is to examine whether our current knowledge of the higher order control of gene expression and nuclear organization can help us understand the mechanisms of genomic imprinting. Imprinting involves the inheritance of a silenced allele of a gene through either a paternal or maternal germline. We have approached the problem of imprinting using a model based on the dynamic attachment of chromatin loops to immobilized RNA polymerases and control elements. We have combined the information from different experimental approaches, examining primarily the IGF2-H19 locus, in an attempt to simplify the complexity of the imprinting data that has accumulated. It is hoped that a unified model may generate predictions amenable to experimental testing and contribute to the interpretation of future experiments.
    Original languageEnglish
    Pages (from-to)1694-1703
    Number of pages9
    JournalFaseb Journal
    Volume15
    Issue number10
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Boundary
    • Chromatin
    • Insulin-like growth factor II
    • Transcription cycles
    • Transcription factories

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