A visible-light photoactivatable di-nuclear Pt IV triazolato azido complex

Kezi Yao, Arnau Bertran, Alison Howarth, Jose M. Goicoechea, Samuel Hare, Nick Rees, Mohammadali Foroozandeh, Alice Bowen, Nicola J. Farrer

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5′-guanosine monophosphate (5′-GMP) produced both PtIV and PtII 5′-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals – particularly hydroxyl radicals – was significantly reduced in the presence of 5′-GMP.
    Original languageEnglish
    JournalChemical Communications
    Issue number75
    DOIs
    Publication statusPublished - 2 Sep 2019

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