A visible-light photoactivatable di-nuclear Pt IV triazolato azido complex

Kezi Yao; Arnau Bertran; Alison Howarth; Jose M. Goicoechea; Samuel Hare; Nick Rees; Mohammadali Foroozandeh; Alice Bowen; Nicola J. Farrer

doi:10.1039/c9cc05310g

A visible-light photoactivatable di-nuclear Pt IV triazolato azido complex

Kezi Yao, Arnau Bertran, Alison Howarth, Jose M. Goicoechea, Samuel Hare, Nick Rees, Mohammadali Foroozandeh, Alice Bowen, Nicola J. Farrer

Oxford University

Research output: Contribution to journal › Article › peer-review

Abstract

A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5′-guanosine monophosphate (5′-GMP) produced both PtIV and PtII 5′-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals – particularly hydroxyl radicals – was significantly reduced in the presence of 5′-GMP.

Original language	English
Journal	Chemical Communications
Issue number	75
DOIs	https://doi.org/10.1039/c9cc05310g
Publication status	Published - 2 Sept 2019

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title = "A visible-light photoactivatable di-nuclear Pt IV triazolato azido complex",

abstract = "A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5′-guanosine monophosphate (5′-GMP) produced both PtIV and PtII 5′-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals – particularly hydroxyl radicals – was significantly reduced in the presence of 5′-GMP.",

author = "Kezi Yao and Arnau Bertran and Alison Howarth and Goicoechea, {Jose M.} and Samuel Hare and Nick Rees and Mohammadali Foroozandeh and Alice Bowen and Farrer, {Nicola J.}",

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doi = "10.1039/c9cc05310g",

language = "English",

journal = "Chemical Communications",

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T1 - A visible-light photoactivatable di-nuclear Pt IV triazolato azido complex

AU - Yao, Kezi

AU - Bertran, Arnau

AU - Howarth, Alison

AU - Goicoechea, Jose M.

AU - Hare, Samuel

AU - Rees, Nick

AU - Foroozandeh, Mohammadali

AU - Bowen, Alice

AU - Farrer, Nicola J.

PY - 2019/9/2

Y1 - 2019/9/2

N2 - A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5′-guanosine monophosphate (5′-GMP) produced both PtIV and PtII 5′-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals – particularly hydroxyl radicals – was significantly reduced in the presence of 5′-GMP.

AB - A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5′-guanosine monophosphate (5′-GMP) produced both PtIV and PtII 5′-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals – particularly hydroxyl radicals – was significantly reduced in the presence of 5′-GMP.

U2 - 10.1039/c9cc05310g

DO - 10.1039/c9cc05310g

M3 - Article

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

IS - 75

ER -

A visible-light photoactivatable di-nuclear Pt IV triazolato azido complex

Abstract

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