TY - JOUR
T1 - Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder
T2 - A Systematic Review
AU - Thawley, Alexandra Jade
AU - Veneziani, Luciana Peixoto
AU - Rabelo-da-Ponte, Francisco Diego
AU - Riederer, Ingo
AU - Mendes-da-Cruz, Daniella Areas
AU - Bambini-Junior, Victorio
N1 - Funding Information:
This study was supported by the University of Central Lancashire, UK; the Oswaldo Cruz Foundation, the National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM, CNPq), the Rio de Janeiro Research Network on Neuroinflammation (RENEURIN - Faperj), Brazil; the MercoSur Fund for Structural Convergence (FOCEM); and the ERASMUS+ programme.
Publisher Copyright:
Copyright © 2022 Thawley, Veneziani, Rabelo-da-Ponte, Riederer, Mendes-da-Cruz and Bambini-Junior.
PY - 2022/6/10
Y1 - 2022/6/10
N2 - Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical findings, the data available is contradictory in offspring but not in the pregnant dams, pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD, whilst there are no alterations described in IL-17 levels in others. To address this gap in the literature, a systematic review of altered IL-17 levels in rodent models of ASD was conducted. In total, 28 studies that explored IL-17 levels were included and observed that this cytokine was generally increased among the different models of ASD. The data compiled in this review can help the choice of animal models to study the role of cytokines in the development of ASD, seeking a parallel with immune alterations observed in individuals with this condition.SYSTEMATIC REVIEW REGISTRATION: PROSPERO, identifier CRD42022306558.
AB - Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical findings, the data available is contradictory in offspring but not in the pregnant dams, pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD, whilst there are no alterations described in IL-17 levels in others. To address this gap in the literature, a systematic review of altered IL-17 levels in rodent models of ASD was conducted. In total, 28 studies that explored IL-17 levels were included and observed that this cytokine was generally increased among the different models of ASD. The data compiled in this review can help the choice of animal models to study the role of cytokines in the development of ASD, seeking a parallel with immune alterations observed in individuals with this condition.SYSTEMATIC REVIEW REGISTRATION: PROSPERO, identifier CRD42022306558.
KW - IL-17
KW - animal model
KW - autism spectrum disorder
KW - inflammation
KW - systematic review
U2 - 10.3389/fimmu.2022.874064
DO - 10.3389/fimmu.2022.874064
M3 - Review article
C2 - 35757754
SN - 1664-3224
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 874064
ER -