Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

W Thomson; L Pepper; A Payton; D Carthy; D Scott; W Ollier; A Silman; D Symmons

doi:10.1136/ard.52.7.539

Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

W Thomson, L Pepper, A Payton, D Carthy, D Scott, W Ollier, A Silman, D Symmons

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis.

Methods: HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis.

Results: The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%).

Conclusions: The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.

Original language	English
Pages (from-to)	539-541
Number of pages	3
Journal	Annals of the rheumatic diseases
Volume	52
Issue number	7
DOIs	https://doi.org/10.1136/ard.52.7.539
Publication status	Published - 1 Jul 1993

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10.1136/ard.52.7.539

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title = "Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community",

abstract = "Objectives: To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. Methods: HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis. Results: The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37\%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18\%). Conclusions: The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.",

author = "W Thomson and L Pepper and A Payton and D Carthy and D Scott and W Ollier and A Silman and D Symmons",

note = "UI - 93349137 LA - eng RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DR1 Antigen) RN - 0 (HLA-DR4 Antigen) RN - 0 (Histocompatibility Antigens Class II) RN - 0 (Oligonucleotide Probes) RN - 128338-86-3 (HLA-DRB1) PT - Journal Article DA - 19930909 IS - 0003-4967 SB - IM CY - ENGLAND",

year = "1993",

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doi = "10.1136/ard.52.7.539",

language = "English",

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T1 - Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

AU - Thomson, W

AU - Pepper, L

AU - Payton, A

AU - Carthy, D

AU - Scott, D

AU - Ollier, W

AU - Silman, A

AU - Symmons, D

N1 - UI - 93349137 LA - eng RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DR1 Antigen) RN - 0 (HLA-DR4 Antigen) RN - 0 (Histocompatibility Antigens Class II) RN - 0 (Oligonucleotide Probes) RN - 128338-86-3 (HLA-DRB1) PT - Journal Article DA - 19930909 IS - 0003-4967 SB - IM CY - ENGLAND

PY - 1993/7/1

Y1 - 1993/7/1

N2 - Objectives: To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. Methods: HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis. Results: The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%). Conclusions: The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.

AB - Objectives: To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis. Methods: HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis. Results: The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%). Conclusions: The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.

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VL - 52

SP - 539

EP - 541

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 7

ER -

Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community

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