Abstract
Objective. To determine whether interleukin 1 alpha (IL-1α) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). Patients and controls. A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. Methods. The IL-1α promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1α intronic microsatellite repeat. Results. No association was observed between IL-1α polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1α polymorphisms and chronic anterior uveitis was found. Conclusions. IL-1α is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1α in Norwegian JCA patients.
Original language | English |
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Pages (from-to) | 171-175 |
Number of pages | 4 |
Journal | Rheumatology |
Volume | 38 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1999 |
Keywords
- Chronic anterior uveitis
- Interleukin 1 alpha
- Juvenile chronic arthritis
- Oligoarticular