Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients

R. P. Donn, A. J. Farhan, J. H. Barrett, W. Thomson, J. Worthington, W. E R Ollier

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective. To determine whether interleukin 1 alpha (IL-1α) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). Patients and controls. A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. Methods. The IL-1α promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1α intronic microsatellite repeat. Results. No association was observed between IL-1α polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1α polymorphisms and chronic anterior uveitis was found. Conclusions. IL-1α is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1α in Norwegian JCA patients.
    Original languageEnglish
    Pages (from-to)171-175
    Number of pages4
    JournalRheumatology
    Volume38
    Issue number2
    DOIs
    Publication statusPublished - Feb 1999

    Keywords

    • Chronic anterior uveitis
    • Interleukin 1 alpha
    • Juvenile chronic arthritis
    • Oligoarticular

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