Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients

R. P. Donn; A. J. Farhan; J. H. Barrett; W. Thomson; J. Worthington; W. E R Ollier

doi:10.1093/rheumatology/38.2.171

Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients

R. P. Donn, A. J. Farhan, J. H. Barrett, W. Thomson, J. Worthington, W. E R Ollier

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. To determine whether interleukin 1 alpha (IL-1α) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). Patients and controls. A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. Methods. The IL-1α promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1α intronic microsatellite repeat. Results. No association was observed between IL-1α polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1α polymorphisms and chronic anterior uveitis was found. Conclusions. IL-1α is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1α in Norwegian JCA patients.

Original language	English
Pages (from-to)	171-175
Number of pages	4
Journal	Rheumatology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1093/rheumatology/38.2.171
Publication status	Published - Feb 1999

Keywords

Chronic anterior uveitis
Interleukin 1 alpha
Juvenile chronic arthritis
Oligoarticular

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10.1093/rheumatology/38.2.171

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title = "Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients",

abstract = "Objective. To determine whether interleukin 1 alpha (IL-1α) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). Patients and controls. A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. Methods. The IL-1α promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1α intronic microsatellite repeat. Results. No association was observed between IL-1α polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1α polymorphisms and chronic anterior uveitis was found. Conclusions. IL-1α is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1α in Norwegian JCA patients.",

keywords = "Chronic anterior uveitis, Interleukin 1 alpha, Juvenile chronic arthritis, Oligoarticular",

author = "Donn, {R. P.} and Farhan, {A. J.} and Barrett, {J. H.} and W. Thomson and J. Worthington and Ollier, {W. E R}",

year = "1999",

month = feb,

doi = "10.1093/rheumatology/38.2.171",

language = "English",

volume = "38",

pages = "171--175",

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T1 - Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients

AU - Donn, R. P.

AU - Farhan, A. J.

AU - Barrett, J. H.

AU - Thomson, W.

AU - Worthington, J.

AU - Ollier, W. E R

PY - 1999/2

Y1 - 1999/2

N2 - Objective. To determine whether interleukin 1 alpha (IL-1α) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). Patients and controls. A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. Methods. The IL-1α promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1α intronic microsatellite repeat. Results. No association was observed between IL-1α polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1α polymorphisms and chronic anterior uveitis was found. Conclusions. IL-1α is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1α in Norwegian JCA patients.

AB - Objective. To determine whether interleukin 1 alpha (IL-1α) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). Patients and controls. A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. Methods. The IL-1α promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1α intronic microsatellite repeat. Results. No association was observed between IL-1α polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1α polymorphisms and chronic anterior uveitis was found. Conclusions. IL-1α is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1α in Norwegian JCA patients.

KW - Chronic anterior uveitis

KW - Interleukin 1 alpha

KW - Juvenile chronic arthritis

KW - Oligoarticular

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DO - 10.1093/rheumatology/38.2.171

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EP - 175

JO - Rheumatology

JF - Rheumatology

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Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients

Abstract

Keywords

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