Absence of TAP 2D in Yoruba Nigerians

A. A O Awomoyi, R. P. Donn, E. J. Davies, D. Carthy, W. Thomson, W. E R Ollier

    Research output: Contribution to journalArticlepeer-review


    We have characterized TAP allele frequencies in a panel of 71 Yoruba Nigerians using ARMS-PCR. With the exception that TAP 2D was absent in Nigerians, TAP 2 allele frequencies in this population were found to be similar to those in a UK white population. HLA-DR4 also was found to be at a low frequency in Yoruba Nigerians (1.4%). This may reflect the absence of TAP 2D in Nigerians as DR4 and TAP 2D are in linkage disequilibrium in UK Caucasoids. The most frequent TAP 1 allele in Yoruba Nigerians was TAP 1A (49%). However, this value will be an underestimate as TAP1 alleles could not be unequivocally assigned in 41% of subjects using the ARMS-PCR methodology.
    Original languageEnglish
    Pages (from-to)187-190
    Number of pages3
    JournalEuropean Journal of Immunogenetics
    Issue number2
    Publication statusPublished - 1995




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