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Abstract
Accurate characterisation of the microstructure of inhaled powders is an essential element in our understanding of dry powder inhalers, yet current methods for measuring critical material attributes such as the particle size and shape suffer from low resolution, image in 2D or make shape assumptions. In this work, we demonstrate how X‐ray Computed Tomography (XCT) is a non‐destructive, fully three‐dimensional technique for characterising inhalation powder blends. Particle size distributions produced through XCT are shown to have good correspondence with those produced through laser diffraction and optical microscopy, whilst XCT sphericity distributions provide a more accurate reflection of the powder shape. This shows the promise for XCT as a valuable powder characterisation technique that develops our fundamental understanding of powder microstructure, a descriptor now required from the United States Food and Drug Administration (Q3 equivalence).
Original language | English |
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Pages | A-1-A-31 |
Number of pages | 4 |
DOIs | |
Publication status | Published - 2 Apr 2020 |
Event | Drug Delivery to the Lungs - Edinburgh International Conference Centre, Edinburgh, United Kingdom Duration: 11 Dec 2019 → 13 Dec 2019 Conference number: 30 |
Conference
Conference | Drug Delivery to the Lungs |
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Country/Territory | United Kingdom |
City | Edinburgh |
Period | 11/12/19 → 13/12/19 |
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Dive into the research topics of 'Abstracts from The Aerosol Society Drug Delivery to the Lungs 30 Edinburgh International Conference Centre Edinburgh, Scotland, UK December 11–13, 2019: A 3D method for characterising inhalation powders'. Together they form a unique fingerprint.Projects
- 1 Finished
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INFORM 2020 - Molecules to Manufacture: Processing and Formulation Engineering of Inhalable Nanoaggregates and Microparticles
Withers, P. (PI) & Burnett, T. (CoI)
1/10/16 → 31/01/21
Project: Research