Acceleration of cutaneous healing by electrical stimulation: Degenerate electrical waveform down-regulates inflammation, up-regulates angiogenesis and advances remodeling in temporal punch biopsies in a human volunteer study

Anil Sebastian, Farhatullah Syed, Donna Perry, Vinayagapriya Balamurugan, James Colthurst, Iskander H. Chaudhry, Ardeshir Bayat

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We previously demonstrated the beneficial effect of a novel electrical stimulation (ES) waveform, degenerate wave (DW) on skin fibroblasts, and now hypothesize that DW can enhance cutaneous wound healing in vivo. Therefore, a punch biopsy was taken from the upper arm of 20 volunteers on day 0 and repeated on day 14 (NSD14). A contralateral upper arm biopsy was taken on day 0 and treated with DW for 14 days prior to a repeat biopsy on day 14 (ESD14). A near-completed inflammatory stage of wound healing in ESD14, compared to NSD14 was demonstrated by up-regulation of interleukin-10 and vasoactive intestinal peptide using quantitative real time polymerase chain reaction and down-regulation of CD3 by immunohistochemistry (IHC) (p
    Original languageEnglish
    Pages (from-to)693-708
    Number of pages15
    JournalWound Repair and Regeneration
    Volume19
    Issue number6
    DOIs
    Publication statusPublished - Nov 2011

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