Acceptor analogues as potential inhibitors of bovine β-1,4-galactosyl transferase

R.A. Field; D.C.A. Neville; R.W. Smith; M.A.J. Ferguson

doi:10.1016/0960-894X(94)80002-2

Acceptor analogues as potential inhibitors of bovine β-1,4-galactosyl transferase

R.A. Field, D.C.A. Neville, R.W. Smith, M.A.J. Ferguson

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase. Of the azido, amino, and acetamido compounds tested, only the 4-amino compound (2) produced significant inhibition of this enzyme.
A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase

Original language	Undefined
Pages (from-to)	391-394
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/0960-894X(94)80002-2
Publication status	Published - 1994

Keywords

Transferases
Derivatives
Enzymes

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1016/0960-894X(94)80002-2

Cite this

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title = "Acceptor analogues as potential inhibitors of bovine β-1,4-galactosyl transferase",

abstract = "A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase. Of the azido, amino, and acetamido compounds tested, only the 4-amino compound (2) produced significant inhibition of this enzyme.A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase",

keywords = "Transferases, Derivatives, Enzymes",

author = "R.A. Field and D.C.A. Neville and R.W. Smith and M.A.J. Ferguson",

year = "1994",

doi = "10.1016/0960-894X(94)80002-2",

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AU - Field, R.A.

AU - Neville, D.C.A.

AU - Smith, R.W.

AU - Ferguson, M.A.J.

PY - 1994

Y1 - 1994

N2 - A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase. Of the azido, amino, and acetamido compounds tested, only the 4-amino compound (2) produced significant inhibition of this enzyme.A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase

AB - A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase. Of the azido, amino, and acetamido compounds tested, only the 4-amino compound (2) produced significant inhibition of this enzyme.A series of 4- and 6-substituted derivatives of benzyl N-acetyl-β-D glucosaminide were prepared and assessed as inhibitors of bovine β-1,4-galactosyl transferase

KW - Transferases

KW - Derivatives

KW - Enzymes

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0028223990&partnerID=MN8TOARS

U2 - 10.1016/0960-894X(94)80002-2

DO - 10.1016/0960-894X(94)80002-2

M3 - Article

SN - 0960-894X

VL - 4

SP - 391

EP - 394

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Acceptor analogues as potential inhibitors of bovine β-1,4-galactosyl transferase

Abstract

Keywords

Research Beacons, Institutes and Platforms

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