Abstract
We describe an extension to our variant calling tool, Octopus (https://github.com/luntergroup/octopus), for single-cell DNA sequencing data. Octopus jointly genotypes cells from a lineage, accounting for amplification stochasticity and sequencing error with a haplotype-based Bayesian model. Octopus is considerably more accurate at genotyping single cells than existing methods.
Original language | English |
---|---|
DOIs | |
Publication status | Published - 3 Jun 2021 |
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre