ACTH precursors characterize the ectopic ACTH syndrome

P. M. Stewart; S. Gibson; S. R. Crosby; R. Penn; R. Holder; D. Ferry; N. Thatcher; P. Phillips; D. R. London; A. White

ACTH precursors characterize the ectopic ACTH syndrome

P. M. Stewart, S. Gibson, S. R. Crosby, R. Penn, R. Holder, D. Ferry, N. Thatcher, P. Phillips, D. R. London, A. White

Research output: Contribution to journal › Article › peer-review

Abstract

Objective - ACTH is secreted by the pituitary following processing of larger molecular weight precursors, proopiomelanocortin and pro-ACTH. Ectopic ACTH syndrome refers to the secretion of ACTH by non-pituitary tumours, but the predominant circulating form of proopiomelanocortin-related peptides remains unclear. Patients Fifteen patients with ectopic ACTH syndrome were compared to 20 patients with pituitary-dependent Cushing's syndrome, 22 patients with small cell lung carcinoma but no evidence of Cushing's syndrome, and 25 controls. Design and Meaurements - Measurement of plasma ACTH and ACTH precursors using specific monoclonal-based immunoradiometric assays at 0900 h and, in five patients with ectopic ACTH syndrome, at 15-minute intervals for 6-24 hours. Results - ACTH precursors were grossly elevated in patients with ectopic ACTH syndrome (median 2194, range 139-18000 pmol/l) compared to patients with Cushing's disease (median 33, 8-73 pmol/l, P

Original language	English
Pages (from-to)	199-204
Number of pages	5
Journal	Clinical Endocrinology
Volume	40
Issue number	2
Publication status	Published - 1994

Keywords

blood: ACTH Syndrome, Ectopic
blood: Adrenocorticotropic Hormone
Adult
Aged
Antibodies, Monoclonal
blood: Carcinoma, Small Cell
blood: Cushing Syndrome
Humans
blood: Hydrocortisone
Immunoradiometric Assay
blood: Lung Neoplasms
Middle Aged
blood: Pro-Opiomelanocortin
blood: Protein Precursors
physiology: Secretory Rate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{1d8439f4ca1943d7bc12650a2134bc1a,

title = "ACTH precursors characterize the ectopic ACTH syndrome",

abstract = "Objective - ACTH is secreted by the pituitary following processing of larger molecular weight precursors, proopiomelanocortin and pro-ACTH. Ectopic ACTH syndrome refers to the secretion of ACTH by non-pituitary tumours, but the predominant circulating form of proopiomelanocortin-related peptides remains unclear. Patients Fifteen patients with ectopic ACTH syndrome were compared to 20 patients with pituitary-dependent Cushing's syndrome, 22 patients with small cell lung carcinoma but no evidence of Cushing's syndrome, and 25 controls. Design and Meaurements - Measurement of plasma ACTH and ACTH precursors using specific monoclonal-based immunoradiometric assays at 0900 h and, in five patients with ectopic ACTH syndrome, at 15-minute intervals for 6-24 hours. Results - ACTH precursors were grossly elevated in patients with ectopic ACTH syndrome (median 2194, range 139-18000 pmol/l) compared to patients with Cushing's disease (median 33, 8-73 pmol/l, P",

keywords = "blood: ACTH Syndrome, Ectopic, blood: Adrenocorticotropic Hormone, Adult, Aged, Antibodies, Monoclonal, blood: Carcinoma, Small Cell, blood: Cushing Syndrome, Humans, blood: Hydrocortisone, Immunoradiometric Assay, blood: Lung Neoplasms, Middle Aged, blood: Pro-Opiomelanocortin, blood: Protein Precursors, physiology: Secretory Rate",

author = "Stewart, \{P. M.\} and S. Gibson and Crosby, \{S. R.\} and R. Penn and R. Holder and D. Ferry and N. Thatcher and P. Phillips and London, \{D. R.\} and A. White",

year = "1994",

language = "English",

volume = "40",

pages = "199--204",

journal = "Clinical Endocrinology",

issn = "1365-2265",

publisher = "John Wiley \& Sons Ltd",

number = "2",

}

TY - JOUR

T1 - ACTH precursors characterize the ectopic ACTH syndrome

AU - Stewart, P. M.

AU - Gibson, S.

AU - Crosby, S. R.

AU - Penn, R.

AU - Holder, R.

AU - Ferry, D.

AU - Thatcher, N.

AU - Phillips, P.

AU - London, D. R.

AU - White, A.

PY - 1994

Y1 - 1994

N2 - Objective - ACTH is secreted by the pituitary following processing of larger molecular weight precursors, proopiomelanocortin and pro-ACTH. Ectopic ACTH syndrome refers to the secretion of ACTH by non-pituitary tumours, but the predominant circulating form of proopiomelanocortin-related peptides remains unclear. Patients Fifteen patients with ectopic ACTH syndrome were compared to 20 patients with pituitary-dependent Cushing's syndrome, 22 patients with small cell lung carcinoma but no evidence of Cushing's syndrome, and 25 controls. Design and Meaurements - Measurement of plasma ACTH and ACTH precursors using specific monoclonal-based immunoradiometric assays at 0900 h and, in five patients with ectopic ACTH syndrome, at 15-minute intervals for 6-24 hours. Results - ACTH precursors were grossly elevated in patients with ectopic ACTH syndrome (median 2194, range 139-18000 pmol/l) compared to patients with Cushing's disease (median 33, 8-73 pmol/l, P

AB - Objective - ACTH is secreted by the pituitary following processing of larger molecular weight precursors, proopiomelanocortin and pro-ACTH. Ectopic ACTH syndrome refers to the secretion of ACTH by non-pituitary tumours, but the predominant circulating form of proopiomelanocortin-related peptides remains unclear. Patients Fifteen patients with ectopic ACTH syndrome were compared to 20 patients with pituitary-dependent Cushing's syndrome, 22 patients with small cell lung carcinoma but no evidence of Cushing's syndrome, and 25 controls. Design and Meaurements - Measurement of plasma ACTH and ACTH precursors using specific monoclonal-based immunoradiometric assays at 0900 h and, in five patients with ectopic ACTH syndrome, at 15-minute intervals for 6-24 hours. Results - ACTH precursors were grossly elevated in patients with ectopic ACTH syndrome (median 2194, range 139-18000 pmol/l) compared to patients with Cushing's disease (median 33, 8-73 pmol/l, P

KW - blood: ACTH Syndrome, Ectopic

KW - blood: Adrenocorticotropic Hormone

KW - Adult

KW - Aged

KW - Antibodies, Monoclonal

KW - blood: Carcinoma, Small Cell

KW - blood: Cushing Syndrome

KW - Humans

KW - blood: Hydrocortisone

KW - Immunoradiometric Assay

KW - blood: Lung Neoplasms

KW - Middle Aged

KW - blood: Pro-Opiomelanocortin

KW - blood: Protein Precursors

KW - physiology: Secretory Rate

UR - https://www.scopus.com/pages/publications/0028271225

M3 - Article

SN - 1365-2265

VL - 40

SP - 199

EP - 204

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 2

ER -

ACTH precursors characterize the ectopic ACTH syndrome

Abstract

Keywords

UN SDGs

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Antibodies to ACTH and related hormones as diagnostic tools

Cite this

ACTH precursors characterize the ectopic ACTH syndrome

Abstract

Keywords

UN SDGs

Other files and links

Fingerprint

Impacts

Antibodies to ACTH and related hormones as diagnostic tools

Cite this