Actin organization and dynamics in filamentous fungi

Adokiye Berepiki; Alexander Lichius; Nick D. Read

doi:10.1038/nrmicro2666

Actin organization and dynamics in filamentous fungi

Adokiye Berepiki, Alexander Lichius, Nick D. Read

Research output: Contribution to journal › Article › peer-review

Abstract

Growth and morphogenesis of filamentous fungi is underpinned by dynamic reorganization and polarization of the actin cytoskeleton. Actin has crucial roles in exocytosis, endocytosis, organelle movement and cytokinesis in fungi, and these processes are coupled to the production of distinct higher-order structures (actin patches, cables and rings) that generate forces or serve as tracks for intracellular transport. New approaches for imaging actin in living cells are revealing important similarities and differences in actin architecture and organization within the fungal kingdom, and have yielded key insights into cell polarity, tip growth and long-distance intracellular transport. In this Review, we discuss the contribution that recent live-cell imaging and mutational studies have made to our understanding of the dynamics and regulation of actin in filamentous fungi. © 2011 Macmillan Publishers Limited. All rights reserved.

Original language	English
Pages (from-to)	876-887
Number of pages	11
Journal	Nature Reviews Microbiology
Volume	9
Issue number	12
DOIs	https://doi.org/10.1038/nrmicro2666
Publication status	Published - Dec 2011

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title = "Actin organization and dynamics in filamentous fungi",

abstract = "Growth and morphogenesis of filamentous fungi is underpinned by dynamic reorganization and polarization of the actin cytoskeleton. Actin has crucial roles in exocytosis, endocytosis, organelle movement and cytokinesis in fungi, and these processes are coupled to the production of distinct higher-order structures (actin patches, cables and rings) that generate forces or serve as tracks for intracellular transport. New approaches for imaging actin in living cells are revealing important similarities and differences in actin architecture and organization within the fungal kingdom, and have yielded key insights into cell polarity, tip growth and long-distance intracellular transport. In this Review, we discuss the contribution that recent live-cell imaging and mutational studies have made to our understanding of the dynamics and regulation of actin in filamentous fungi. {\textcopyright} 2011 Macmillan Publishers Limited. All rights reserved.",

author = "Adokiye Berepiki and Alexander Lichius and Read, {Nick D.}",

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AU - Lichius, Alexander

AU - Read, Nick D.

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PY - 2011/12

Y1 - 2011/12

N2 - Growth and morphogenesis of filamentous fungi is underpinned by dynamic reorganization and polarization of the actin cytoskeleton. Actin has crucial roles in exocytosis, endocytosis, organelle movement and cytokinesis in fungi, and these processes are coupled to the production of distinct higher-order structures (actin patches, cables and rings) that generate forces or serve as tracks for intracellular transport. New approaches for imaging actin in living cells are revealing important similarities and differences in actin architecture and organization within the fungal kingdom, and have yielded key insights into cell polarity, tip growth and long-distance intracellular transport. In this Review, we discuss the contribution that recent live-cell imaging and mutational studies have made to our understanding of the dynamics and regulation of actin in filamentous fungi. © 2011 Macmillan Publishers Limited. All rights reserved.

AB - Growth and morphogenesis of filamentous fungi is underpinned by dynamic reorganization and polarization of the actin cytoskeleton. Actin has crucial roles in exocytosis, endocytosis, organelle movement and cytokinesis in fungi, and these processes are coupled to the production of distinct higher-order structures (actin patches, cables and rings) that generate forces or serve as tracks for intracellular transport. New approaches for imaging actin in living cells are revealing important similarities and differences in actin architecture and organization within the fungal kingdom, and have yielded key insights into cell polarity, tip growth and long-distance intracellular transport. In this Review, we discuss the contribution that recent live-cell imaging and mutational studies have made to our understanding of the dynamics and regulation of actin in filamentous fungi. © 2011 Macmillan Publishers Limited. All rights reserved.

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JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

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ER -

Actin organization and dynamics in filamentous fungi

Abstract

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