TY - JOUR
T1 - Actions of a coral toxin analogue (bipinnatin-B) on an insect nicotinic acetylcholine receptor.
AU - Bai, D.
AU - Abramson, S. N.
AU - Sattelle, D. B.
PY - 1993
Y1 - 1993
N2 - The lophotoxin analogue, bipinnatin-B, is a potent neurotoxin isolated from the gorgonian coral Pseudopterogorgia bipinnata. When tested on the cell body of an identified motor neurone, the fast coxal depressor motor neurone (Df) in the cockroach metathoracic ganglion, bipinnatin-B, at concentrations of 10 micronM,partially blocked nicotine-induced depolarization. Blockade of the response to nicotine was almost complete at 30 micronM bipinnatin-B, and was partially reversible on rebathing the preparation in normal saline. Responses of the same neurone to GABA were unaffected by 30 micronM bipinnatin-B.
AB - The lophotoxin analogue, bipinnatin-B, is a potent neurotoxin isolated from the gorgonian coral Pseudopterogorgia bipinnata. When tested on the cell body of an identified motor neurone, the fast coxal depressor motor neurone (Df) in the cockroach metathoracic ganglion, bipinnatin-B, at concentrations of 10 micronM,partially blocked nicotine-induced depolarization. Blockade of the response to nicotine was almost complete at 30 micronM bipinnatin-B, and was partially reversible on rebathing the preparation in normal saline. Responses of the same neurone to GABA were unaffected by 30 micronM bipinnatin-B.
U2 - 10.1002/arch.940230402
DO - 10.1002/arch.940230402
M3 - Article
C2 - 21313781
VL - 23
SP - 155
EP - 159
JO - Archives of insect biochemistry and physiology
JF - Archives of insect biochemistry and physiology
IS - 4
ER -