Actions of acromelic acid on nervous system L-glutamate receptors.

D. B. Sattelle, M. I. Sepúlveda, H. Shinozaki, M. Ishida

    Research output: Contribution to journalArticlepeer-review


    Acromelic acid, a naturally occurring kainoid, isolated from the mushroom Clitocybe acromelalga, is a weak displacer of [3H]L-glutamate binding to cockroach (Periplaneta americana) nerve cord membranes. Acromelic acid (1 mM) displaces approximately 60% of specifically bound [3H]L-glutamate. When applied by bath perfusion to the cell body membrane of the cockroach fast coxal depressor motor neurone, acromelic acid generated slow, prolonged, dose-dependent depolarizations at concentrations of 0.3 microM and above. Thus acromelic acid is among the most potent of the excitatory amino acids tested to date on insect neurones.
    Original languageEnglish
    Pages (from-to)87-94
    Number of pages7
    JournalArchives of insect biochemistry and physiology
    Issue number2
    Publication statusPublished - 1994


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