Activation of transient receptor potential vanilloid-3 inhibits human hair growth

István Borbíró, Erika Lisztes, Balázs I. Tóth, Gabriella Czifra, Attila Oláh, Attila G. Szöllsi, Norbert Szentandrássy, Péter P. Nánási, Zoltán Péter, Ralf Paus, László Kovács, Tamás Bíró

    Research output: Contribution to journalArticlepeer-review


    In the current study, we aimed at identifying the functional role of transient receptor potential vanilloid-3 (TRPV3) ion channel in the regulation of human hair growth. Using human organ-cultured hair follicles (HFs) and cultures of human outer root sheath (ORS) keratinocytes, we provide the first evidence that activation of TRPV3 inhibits human hair growth. TRPV3 immunoreactivity was confined to epithelial compartments of the human HF, mainly to the ORS. In organ culture, TRPV3 activation by plant-derived (e.g., eugenol, 10-1,000 M) or synthetic (e.g., 2-aminoethoxydiphenyl borate, 1-300 M) agonists resulted in a dose-dependent inhibition of hair shaft elongation, suppression of proliferation, and induction of apoptosis and premature HF regression (catagen). Human ORS keratinocytes also expressed functional TRPV3, whose stimulation induced membrane currents, elevated intracellular calcium concentration, inhibited proliferation, and induced apoptosis. Of great importance, these effects on ORS keratinocytes were all mediated by TRPV3, as small interfering RNA-mediated silencing of TRPV3 effectively abrogated the cellular actions of the above agonists. These findings collectively support the concept that TRPV3 signaling is a significant player in human hair growth control. Therefore, TRPV3 and the related intracellular signaling mechanism might function as a promising target for pharmacological manipulations of clinically relevant hair growth disorders. © 2011 The Society for Investigative Dermatology.
    Original languageEnglish
    Pages (from-to)1605-1614
    Number of pages9
    JournalJournal of Investigative Dermatology
    Issue number8
    Publication statusPublished - Aug 2011


    Dive into the research topics of 'Activation of transient receptor potential vanilloid-3 inhibits human hair growth'. Together they form a unique fingerprint.

    Cite this