Active Surveillance in 2020: A modified Delphi study to develop a practical guide for selecting patients with prostate cancer for Active Surveillance

S Merriel, D Moon, P Dundee, Niall M Corcoran, P Carroll, A W Partin, J Smith, Freddie C. Hamdy, C Moore, P Ost, T Costello

Research output: Working paperPreprint

Abstract

Background: Active surveillance (AS) is a management option for men diagnosed with lower risk prostate cancer. There is wide variation in all aspects of AS internationally, from patient selection to investigations and follow-up intervals, and a lack of clear evidence on the optimal approach to AS. This study aimed to provide guidance for clinicians from an international panel of prostate cancer experts.

Methods: A modified Delphi approach was undertaken, utilising two rounds of online questionnaires followed by a face-to-face workshop. Participants indicated their level of agreement with statements relating to patient selection for AS via online questionnaires on a 7-point Likert scale. Factors not achieving agreement were iteratively developed between the two rounds of questionnaires. Draft statements were presented at the face-to-face workshop for discussion and consensus building.

Results: 12 prostate cancer experts (9 Urologists, 2 academics, 1 radiation oncologist) participated in this study from a range of geographical regions (4 USA, 4 Europe, 4 Australia). Complete agreement on statements presented to the participants was 29.4% after Round One and 69.5% after Round Two. Following robust discussions at the face-to-face workshop, agreement was reached on the remaining statements.

Conclusions: The lack of consistency in the practice of AS for men with lower risk prostate cancer between and within countries was reflected in this modified Delphi study. There are, however, areas of common practice and agreement from which clinicians practicing in the current environment can use to inform their clinical practice to achieve the best outcomes for patients.
Original languageEnglish
PublisherResearch Square
Pages1-15
Number of pages5
DOIs
Publication statusPublished - 9 Dec 2020

Keywords

  • prostate cancer
  • cancer treatment protocols
  • patient selection
  • active surveillance

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