Activity and osmotic coefficients of promethazine and chlorpromazine hydrochlorides in aqueous solutions of low ionic strength

Juan M. Ruso; David Attwood; Pablo Taboada; María J. Suárez; Félix Sarmiento; Víctor Mosquera

doi:10.1021/je990001a

Activity and osmotic coefficients of promethazine and chlorpromazine hydrochlorides in aqueous solutions of low ionic strength

Juan M. Ruso
, David Attwood
, Pablo Taboada
, María J. Suárez
, Félix Sarmiento
, Víctor Mosquera

Research output: Contribution to journal › Article › peer-review

Abstract

Osmotic and activity coefficients of amphiphilic drugs chlorpromazine hydrochloride and promethazine hydrochloride in aqueous solutions have been derived from vapor pressure measurements, in the presence of low concentrations of added electrolyte at the temperature 303.15 K. With sufficient time, the system reaches a steady state. When the vapor pressure measurements were made in the presence of electrolyte, the composition of the solvent droplet contained a fixed composition of sodium chloride in water and the solute droplet the drug and sodium chloride at the same composition. An inflection point was detected for both phenothiazine drugs identified as a critical concentration.

Original language	English
Pages (from-to)	941-943
Number of pages	2
Journal	Journal of Chemical and Engineering Data
Volume	44
Issue number	5
DOIs	https://doi.org/10.1021/je990001a
Publication status	Published - Sept 1999

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title = "Activity and osmotic coefficients of promethazine and chlorpromazine hydrochlorides in aqueous solutions of low ionic strength",

abstract = "Osmotic and activity coefficients of amphiphilic drugs chlorpromazine hydrochloride and promethazine hydrochloride in aqueous solutions have been derived from vapor pressure measurements, in the presence of low concentrations of added electrolyte at the temperature 303.15 K. With sufficient time, the system reaches a steady state. When the vapor pressure measurements were made in the presence of electrolyte, the composition of the solvent droplet contained a fixed composition of sodium chloride in water and the solute droplet the drug and sodium chloride at the same composition. An inflection point was detected for both phenothiazine drugs identified as a critical concentration.",

author = "Ruso, \{Juan M.\} and David Attwood and Pablo Taboada and Su{\'a}rez, \{Mar{\'i}a J.\} and F{\'e}lix Sarmiento and V{\'i}ctor Mosquera",

year = "1999",

month = sep,

doi = "10.1021/je990001a",

language = "English",

volume = "44",

pages = "941--943",

journal = "Journal of Chemical and Engineering Data",

publisher = "American Chemical Society",

number = "5",

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TY - JOUR

T1 - Activity and osmotic coefficients of promethazine and chlorpromazine hydrochlorides in aqueous solutions of low ionic strength

AU - Ruso, Juan M.

AU - Attwood, David

AU - Taboada, Pablo

AU - Suárez, María J.

AU - Sarmiento, Félix

AU - Mosquera, Víctor

PY - 1999/9

Y1 - 1999/9

N2 - Osmotic and activity coefficients of amphiphilic drugs chlorpromazine hydrochloride and promethazine hydrochloride in aqueous solutions have been derived from vapor pressure measurements, in the presence of low concentrations of added electrolyte at the temperature 303.15 K. With sufficient time, the system reaches a steady state. When the vapor pressure measurements were made in the presence of electrolyte, the composition of the solvent droplet contained a fixed composition of sodium chloride in water and the solute droplet the drug and sodium chloride at the same composition. An inflection point was detected for both phenothiazine drugs identified as a critical concentration.

AB - Osmotic and activity coefficients of amphiphilic drugs chlorpromazine hydrochloride and promethazine hydrochloride in aqueous solutions have been derived from vapor pressure measurements, in the presence of low concentrations of added electrolyte at the temperature 303.15 K. With sufficient time, the system reaches a steady state. When the vapor pressure measurements were made in the presence of electrolyte, the composition of the solvent droplet contained a fixed composition of sodium chloride in water and the solute droplet the drug and sodium chloride at the same composition. An inflection point was detected for both phenothiazine drugs identified as a critical concentration.

U2 - 10.1021/je990001a

DO - 10.1021/je990001a

M3 - Article

VL - 44

SP - 941

EP - 943

JO - Journal of Chemical and Engineering Data

JF - Journal of Chemical and Engineering Data

IS - 5

ER -

Activity and osmotic coefficients of promethazine and chlorpromazine hydrochlorides in aqueous solutions of low ionic strength

Abstract

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