Activity of topically applied leukotriene B4 in experimental dermatophytosis

G. S. Shankland, M. D. Richardson

    Research output: Contribution to journalArticlepeer-review


    In a pilot study to assess the antimycotic potential of the chemoattractant leukotriene B4 (LTB4), guinea pigs were infected with Trichotphyton mentagrophytes var. mentagrophytes and divided into groups of untreated control animals or treated daily with LTB4, isoconazole nitrate or vehicle alone. The animals were assessed clinically, mycologically and histopathologically. Treatment with isoconazole nitrate was the most effective. The LTB4-treated group were clinically worse than the non-treated group and the mycological results remained positive throughout the assessment period.
    Original languageEnglish
    Pages (from-to)329-334
    Number of pages5
    Issue number11-12
    Publication statusPublished - 1992


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