TY - JOUR
T1 - Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
AU - PHOSP-COVID Study Collaborative Group
AU - Taquet, Maxime
AU - Skorniewska, Zuzanna
AU - Hampshire, Adam
AU - Chalmers, James d.
AU - Ho, Ling-Pei
AU - Horsley, Alex
AU - Marks, Michael
AU - Poinasamy, Krisnah
AU - Raman, Betty
AU - Leavy, Olivia c.
AU - Richardson, Matthew
AU - Elneima, Omer
AU - Mcauley, Hamish j. c.
AU - Shikotra, Aarti
AU - Singapuri, Amisha
AU - Sereno, Marco
AU - Saunders, Ruth m.
AU - Harris, Victoria c.
AU - Houchen-Wolloff, Linzy
AU - Greening, Neil j.
AU - Mansoori, Parisa
AU - Harrison, Ewen m.
AU - Docherty, Annemarie b.
AU - Lone, Nazir i.
AU - Quint, Jennifer
AU - Sattar, Naveed
AU - Brightling, Christopher e.
AU - Wain, Louise v.
AU - Evans, Rachael e.
AU - Geddes, John r.
AU - Harrison, Paul j.
AU - Horsley, Alexander
PY - 2023/8/31
Y1 - 2023/8/31
N2 - Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized with COVID-19, we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19. A first profile links elevated fibrinogen relative to C-reactive protein with both objective and subjective cognitive deficits. A second profile links elevated D-dimer relative to C-reactive protein with subjective cognitive deficits and occupational impact. This second profile was mediated by fatigue and shortness of breath. Neither profile was significantly mediated by depression or anxiety. Results were robust across secondary analyses. They were replicated, and their specificity to COVID-19 tested, in a large-scale electronic health records dataset. These findings provide insights into the heterogeneous biology of post-COVID cognitive deficits.
AB - Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized with COVID-19, we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19. A first profile links elevated fibrinogen relative to C-reactive protein with both objective and subjective cognitive deficits. A second profile links elevated D-dimer relative to C-reactive protein with subjective cognitive deficits and occupational impact. This second profile was mediated by fatigue and shortness of breath. Neither profile was significantly mediated by depression or anxiety. Results were robust across secondary analyses. They were replicated, and their specificity to COVID-19 tested, in a large-scale electronic health records dataset. These findings provide insights into the heterogeneous biology of post-COVID cognitive deficits.
U2 - 10.1038/s41591-023-02525-y
DO - 10.1038/s41591-023-02525-y
M3 - Article
SN - 1078-8956
VL - 29
SP - 2498
EP - 2508
JO - Nature Medicine
JF - Nature Medicine
IS - 10
ER -
