Acyloxymethyl and 4-acyloxybenzyl diester prodrugs of phosphonoformate

Andrew D. Briggs, Michel Camplo, Sally Freeman, Jan Lundström, Brian G. Pring

    Research output: Contribution to journalArticlepeer-review


    Sodium pivaloyloxymethyl (pivaloyloxymethoxycarbonyl)phosphonate 4, sodium 4-acyloxybenzyl phenoxycarbonylphosphonates 14a-c and sodium 4-acyloxybenzyl benzyloxycarbonylphosphonates 15a,b have been prepared as bioreversible prodrugs of the antiviral phosphonoformate 1. Their hydrolyses, in vivo systemic bioavailability and antiviral activity are reported. Of the compounds evaluated 4 was the best prodrug.
    Original languageEnglish
    Pages (from-to)14937-14950
    Number of pages13
    Issue number47
    Publication statusPublished - 18 Nov 1996


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